Genomic meta-analyses of binge-eating behavior and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes.
Eating disorders-including anorexia nervosa (AN), bulimia nervosa and binge-eating disorder-are clinically distinct but exhibit symptom overlap and diagnostic crossover. Genomic analyses have mostly examined AN. Here we conducted a genomic meta-analysis of case-control studies of binge-eating behavior (BE; 39,279 cases, 1,227,436 controls), alongside analyses of AN (24,223 cases, 1,243,971 controls) and its subtypes (all European ancestries). We identified six BE-associated loci, including loci associated with a higher body mass index and impulse-control behaviors. AN genome-wide association studies yielded eight loci, validating six loci. Subsequent polygenic risk score analysis demonstrated an association with AN in two East Asian ancestry studies. BE and AN exhibited similar positive genetic correlations with psychiatric disorders but opposing genetic correlations with anthropometric traits. Most of the genetic signal in BE and AN was not shared with body mass index. We have extended eating disorder genomics beyond AN; future work will incorporate multiple diagnoses and global ancestries.
Authors
Termorshuizen Termorshuizen, Davies Davies, Lee Lee, Dennis Dennis, Hübel Hübel, Johnson Johnson, Lu Lu, Munn-Chernoff Munn-Chernoff, Peters Peters, Qi Qi, Schaumberg Schaumberg, Signer Signer, Singh Singh, Ter Kuile Ter Kuile, Thornton Thornton, Xu Xu, Yao Yao, Yilmaz Yilmaz, Zhang Zhang, Zvrskovec Zvrskovec, Abdulkadir Abdulkadir, Ayorech Ayorech, Corfield Corfield, Havdahl Havdahl, Krebs Krebs, Mack Mack, Niarchou Niarchou, Palviainen Palviainen, Sealock Sealock, Baker Baker, Bergen Bergen, Birgegård Birgegård, Boraska Perica Boraska Perica, Bühren Bühren, Burghardt Burghardt, Cassina Cassina, Castellini Castellini, Collantoni Collantoni, Crowley Crowley, Danner Danner, Degenhardt Degenhardt, DeSocio DeSocio, Dina Dina, Dmitrzak-Węglarz Dmitrzak-Węglarz, Duncan Duncan, Egberts Egberts, Foretova Foretova, Giegling Giegling, Gonidakis Gonidakis, Gordon Gordon, Grove Grove, Guillaume Guillaume, Guintivano Guintivano, Hartmann Hartmann, Hatzikotoulas Hatzikotoulas, Herms Herms, Imgart Imgart, Jiménez-Murcia Jiménez-Murcia, Julià Julià, Kalsi Kalsi, Kaminská Kaminská, Karhunen Karhunen, Kennedy Kennedy, Kiezebrink Kiezebrink, Kolb Kolb, Larsen Larsen, Li Li, Lilenfeld Lilenfeld, Maj Maj, Mattingsdal Mattingsdal, Meneguzzo Meneguzzo, Miller Miller, Mitchell Mitchell, Monteleone Monteleone, Olsen Olsen, Padyukov Padyukov, Parker Parker, Pettie Pettie, Pinto Pinto, Raevuori Raevuori, Ripatti Ripatti, Roberts Roberts, Santonastaso Santonastaso, Savva Savva, Schmidt Schmidt, Schosser Schosser, Seitz Seitz, Slachtova Slachtova, Slopien Slopien, Sorbi Sorbi, Straub Straub, Szatkiewicz Szatkiewicz, Tam Tam, Tenconi Tenconi, Tortorella Tortorella, Tsitsika Tsitsika, van Elburg van Elburg, Wagner Wagner, Watson Watson, Adan Adan, Alfredsson Alfredsson, Andreassen Andreassen, Ask Ask, Børglum Børglum, Brandt Brandt, Collier Collier, Crawford Crawford, Crow Crow, Davis Davis, de Zwaan de Zwaan, Dedoussis Dedoussis, Dick Dick, Ehrlich Ehrlich, Estivill Estivill, Favaro Favaro, Fernández-Aranda Fernández-Aranda, Fischer Fischer, Forstner Forstner, Gorwood Gorwood, Hakonarson Hakonarson, Hebebrand Hebebrand, Herpertz-Dahlmann Herpertz-Dahlmann, Hinney Hinney, Hudson Hudson, Johnson Johnson, Jordan Jordan, Kaplan Kaplan, Kaprio Kaprio, Karwautz Karwautz, Kas Kas, Kaye Kaye, Kennedy Kennedy, Kennedy Kennedy, Keski-Rahkonen Keski-Rahkonen, Kim Kim, Klump Klump, Landén Landén, Le Hellard Le Hellard, Lehto Lehto, Li Li, Lissowska Lissowska, Luykx Luykx, Maguire Maguire, Martin Martin, Mattheisen Mattheisen, Medland Medland, Mehler Mehler, Micali Micali, Mitchell Mitchell, Monteleone Monteleone, Mortensen Mortensen, Nacmias Nacmias, Ophoff Ophoff, Papezova Papezova, Pedersen Pedersen, Petersen Petersen, Rajcsanyi Rajcsanyi, Ramoz Ramoz, Reichborn-Kjennerud Reichborn-Kjennerud, Ricca Ricca, Ripke Ripke, Rujescu Rujescu, Rybakowski Rybakowski, Scherer Scherer, Slof-Op 't Landt Slof-Op 't Landt, Steiger Steiger, Sullivan Sullivan, Świątkowska Świątkowska, van Furth van Furth, Wade Wade, Werge Werge, Whiteman Whiteman, Woodside Woodside, Wu Wu, Zipfel Zipfel, , , Bulik Bulik, Huckins Huckins, Breen Breen, Coleman Coleman,
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