Clinical modifiers of the association between type 1 diabetes and dementia incidence.
Type 1 diabetes mellitus (T1DM) increases dementia risk. Understanding clinical modifiers of that effect could inform prevention.
We analyzed data from All of Us. Participants were aged ≥50 years with T1DM (n = 5,442) or no diabetes (n = 226,819).
Among 232,261 participants (mean [SD] age 64.5 [9.0] years; 57.3% women), 2.3% had a T1DM diagnosis. Among those without diabetes, each additional comorbidity corresponded to a dementia hazard ratio (HR) of 1.22 (95% CI: 1.19, 1.26). The dementia HR among participants with both T1DM and depression, compared with having neither, was pronounced (HR: 5.47 [95% CI: 4.23, 7.08]) and consistent with the independent associations of T1DM alone (HR: 2.01 [95% CI:1.38, 2.92]) and depression alone (HR: 2.55 [95% CI: 2.22, 2.95]).
Individuals who have both T1DM and depression are at especially high risk for dementia.
We analyzed data from All of Us. Participants were aged ≥50 years with T1DM (n = 5,442) or no diabetes (n = 226,819).
Among 232,261 participants (mean [SD] age 64.5 [9.0] years; 57.3% women), 2.3% had a T1DM diagnosis. Among those without diabetes, each additional comorbidity corresponded to a dementia hazard ratio (HR) of 1.22 (95% CI: 1.19, 1.26). The dementia HR among participants with both T1DM and depression, compared with having neither, was pronounced (HR: 5.47 [95% CI: 4.23, 7.08]) and consistent with the independent associations of T1DM alone (HR: 2.01 [95% CI:1.38, 2.92]) and depression alone (HR: 2.55 [95% CI: 2.22, 2.95]).
Individuals who have both T1DM and depression are at especially high risk for dementia.
Authors
Pederson Pederson, Buto Buto, Zimmerman Zimmerman, Velez Velez, Sims Sims, Murchland Murchland, Wang Wang, Glymour Glymour, Spartano Spartano, Weuve Weuve, Gilsanz Gilsanz, Chi Chi, Whitmer Whitmer, Brennan Brennan
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