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In recent years, the promotion of multidisciplinary care and the heightened focus on patients' physical and mental well-being have sparked increased research interest in the mental health burden associated with ophthalmic diseases. In response, we assembled a multidisciplinary team of ophthalmologists, psychiatrists, neurobiologists, and computer scientists to create a systematic and forward-looking overview aimed at guiding future research in both fundamentals of life sciences and brain-computer interface as well as clinical practice. This overview centers on mood disorders, the most prevalent psychiatric conditions among this population. We integrate evidence on the neural, humoral, and inflammatory mechanisms that connect eye disease to mood dysregulation, while also detailing the ocular manifestations typical of mood-disordered patients, including their unique features and underlying mechanisms. Furthermore, we catalog current and emerging ophthalmic and psychiatric diagnostic tools and therapeutic strategies. Finally, we propose a comprehensive multidisciplinary framework for screening, treatment, patient education, and long-term follow-up, providing researchers and clinicians with an evidence-based resource for integrated care.