A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases.
Cardiovascular diseases (CVD) remain a major global health challenge. Early markers of disease initiation and progression are urgently needed. We, and others, have previously shown changes in the gut microbiome in association with metabolic and CVD. Here, we demonstrate that gut microbiome-related changes can be detected in association with subclinical variations in heart and kidney function. Markers related to gut microbial metabolism of aromatic amino acids, phenylalanine and tyrosine, associate with circulating pro-atrial natriuretic peptide and estimated glomerular filtration rate in a metabolically healthy European population. Observational and genetic evidence further identify microbiome-related metabolites as mediators of this gut microbiome-kidney axis, with their baseline levels associating with incident CVD in an external Canadian population. Altogether, our work suggests that the gut microbiome interacts with the cardiorenal axis and participates in an interorgan crosstalk affecting host physiology and risk of CVD.
Authors
Chechi Chechi, Chakaroun Chakaroun, Myridakis Myridakis, Forslund-Startceva Forslund-Startceva, Fromentin Fromentin, Nielsen Nielsen, Aron-Wisneswky Aron-Wisneswky, Belda Belda, Prifti Prifti, Lassen Lassen, Falony Falony, Vieira-Silva Vieira-Silva, Chilloux Chilloux, Sonomura Sonomura, Hoyles Hoyles, Martinez-Gili Martinez-Gili, Pallotti Pallotti, Andrikopoulos Andrikopoulos, Puig-Castellví Puig-Castellví, Tapia Tapia, Castro-Dionicio Castro-Dionicio, Roume Roume, Pons Pons, Le Chatelier Le Chatelier, Quinquis Quinquis, Galleron Galleron, Berland Berland, Olanipekun Olanipekun, Jia Jia, Manolias Manolias, Holmes Holmes, Adriouch Adriouch, Blüher Blüher, Coelho Coelho, Da Silva Da Silva, Galan Galan, Ji Ji, Neves Neves, Rouault Rouault, Salem Salem, Tremaroli Tremaroli, Hansen Hansen, Søndertoft Søndertoft, Lewinter Lewinter, Pedersen Pedersen, , Mark Mark, Goetze Goetze, Køber Køber, Vestergaard Vestergaard, Hansen Hansen, Zucker Zucker, Sato Sato, Hercberg Hercberg, Bäckhed Bäckhed, Letunic Letunic, Oppert Oppert, Nielsen Nielsen, Raes Raes, Tzoulaki Tzoulaki, Dehghan Dehghan, Zuber Zuber, Bouzigon Bouzigon, Lathrop Lathrop, Raina Raina, Froguel Froguel, Matsuda Matsuda, Demenais Demenais, Gauguier Gauguier, Stumvoll Stumvoll, Bork Bork, Pedersen Pedersen, Ehrlich Ehrlich, Clément Clément, Dumas Dumas
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