A systematic review of the frequency of sleep evaluations, sleep disorders, and treatments among individuals with muscular dystrophy.
Review literature on the frequency of sleep disorders and receipt of sleep-related healthcare among individuals with muscular dystrophy.
Included: Population-Duchenne/Becker (DBMD), congenital (CMD), facioscapulohumeral (FSHD), limb-girdle (LGMD), or myotonic (DM) muscular dystrophy; Outcomes-frequency of sleep evaluations, disorders, or treatments; Language-English; Study type-original research, systematic review. Excluded: Sample <10, duplicate reports.
PubMed and EBSCO, last searched March 7, 2023. Risk of bias assessment : Recruitment source or study inclusion selected for or against sleep symptoms or disorders.
Range and weighted average (low risk studies only) of outcome.
We included 95 studies of sleep evaluations (7), disorders (94) or treatments (13) with a total of 7,964 participants. Studies reported on DM-61, DBMD-20, FSHD-9, CMD-1, LGMD-1, and multiple MD-3. One-half of people with DBMD (51%, 2 studies, 85 individuals) and over 60% of people with DM1 (65%, 2 studies, 327 individuals) had a sleep study. Measured by questionnaire, excessive daytime sleepiness frequency among adults with DM was 39% (DM2, 10, 284) to 65% (any DM, 6, 1195), 9% among controls (5, 199), and 6% to 13% among other MDs. Sleep apnea frequency was 11% (LGMD, 1, 18) to 65% (CMD, 1, 20). Assisted ventilation use was 5%-16% (DM).
Regular sleep evaluations may improve identification and treatment of sleep disorders and the physical and mental health of individuals with MD.
Funding-US Centers for Disease Control and Prevention. Not registered.
Included: Population-Duchenne/Becker (DBMD), congenital (CMD), facioscapulohumeral (FSHD), limb-girdle (LGMD), or myotonic (DM) muscular dystrophy; Outcomes-frequency of sleep evaluations, disorders, or treatments; Language-English; Study type-original research, systematic review. Excluded: Sample <10, duplicate reports.
PubMed and EBSCO, last searched March 7, 2023. Risk of bias assessment : Recruitment source or study inclusion selected for or against sleep symptoms or disorders.
Range and weighted average (low risk studies only) of outcome.
We included 95 studies of sleep evaluations (7), disorders (94) or treatments (13) with a total of 7,964 participants. Studies reported on DM-61, DBMD-20, FSHD-9, CMD-1, LGMD-1, and multiple MD-3. One-half of people with DBMD (51%, 2 studies, 85 individuals) and over 60% of people with DM1 (65%, 2 studies, 327 individuals) had a sleep study. Measured by questionnaire, excessive daytime sleepiness frequency among adults with DM was 39% (DM2, 10, 284) to 65% (any DM, 6, 1195), 9% among controls (5, 199), and 6% to 13% among other MDs. Sleep apnea frequency was 11% (LGMD, 1, 18) to 65% (CMD, 1, 20). Assisted ventilation use was 5%-16% (DM).
Regular sleep evaluations may improve identification and treatment of sleep disorders and the physical and mental health of individuals with MD.
Funding-US Centers for Disease Control and Prevention. Not registered.
Authors
Whitehead Whitehead, Alese Alese, Hill Hill, Enger Enger, Zimmerman Zimmerman, Moore Moore, Royer Royer, Venkatash Venkatash, Thomas Thomas, Do Do, Jr Howard Jr Howard
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