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Hashimoto's disease is a thyroid disorder characterized by elevated antibody levels and altered gland structure seen on ultrasound. It is a common autoimmune disease, primarily affecting women. The disease has both physical and psychological consequences. Studies indicate an increased risk of mental health disorders, including depression and anxiety disorders. There is very little research in the literature focused on the quality of life of patients with Hashimoto's disease and social support. The aim of the study was to verify the hypothesis that social support predicts health-related quality of life in patients with Hashimoto's disease, both directly and indirectly. 143 women (aged 19-67) participated in the study. Participants completed a series of questionnaires. The mediation analyses have revealed that disease acceptance mediates the relationship between social support and the perceived impact of Hashimoto's disease on quality of life. The present study thus provides new knowledge in the understudied area of social support, acceptance, and quality of life in women with Hashimoto's disease. It is crucial to highlight the importance of ensuring the availability of psychological support for patients diagnosed with Hashimoto's thyroiditis.