Antecedent of Pregnancy-Related Cardiometabolic Complication and Risk of Cardiovascular Disease Among Women With Type 2 Diabetes.
We investigated the contribution of antecedent gestational diabetes mellitus (GDM) or gestational hypertensive disorder (GHTD) to the risk of cardiovascular disease (CVD) among women with Type 2 diabetes mellitus (T2DM).
In a population-based cohort using the Ministry of Health of Ontario (Canada) healthcare administrative data, women without prior CVD with T2DM and a history of GDM or GHTD as of 1 January 2018 (n = 11 525, mean age: 43 years) were age-matched to three comparator cohorts (women with T2DM and no history of GDM or GHTD [n = 11 525], women without T2DM and without GDM or GHTD [n = 11 525] and men with T2DM [n = 11 525]). Incident CVD (coronary artery disease [CAD] and cerebrovascular disease) and heart failure (HF) were assessed until 31 December 2023.
There were 1231 CVD events over a median follow-up of 6 years. Compared to women with T2DM but no history of GDM or GHTD, women with T2DM and a history of GDM or GHTD exhibited higher incident CVD (adjusted hazard ratio [aHR]: 1.19, 95% CI: 1.01, 1.41) and CAD (aHR: 1.35, 95% CI: 1.10, 1.66) risks. They also had higher CVD (aHR: 3.70, 95% CI: 2.79, 4.91), CAD (aHR: 4.96, 95% CI: 3.43, 7.19), cerebrovascular disease (aHR: 2.41, 95% CI: 1.54, 3.76) and HF (aHR: 4.95, 95% CI: 2.05, 11.94) risks versus women without T2DM and no history of GDM or GHTD. However, they had lower CVD, CAD, cerebrovascular disease and HF risks, compared to men with T2DM.
Among women with T2DM, prior GDM or GHTD conferred a higher CVD risk.
In a population-based cohort using the Ministry of Health of Ontario (Canada) healthcare administrative data, women without prior CVD with T2DM and a history of GDM or GHTD as of 1 January 2018 (n = 11 525, mean age: 43 years) were age-matched to three comparator cohorts (women with T2DM and no history of GDM or GHTD [n = 11 525], women without T2DM and without GDM or GHTD [n = 11 525] and men with T2DM [n = 11 525]). Incident CVD (coronary artery disease [CAD] and cerebrovascular disease) and heart failure (HF) were assessed until 31 December 2023.
There were 1231 CVD events over a median follow-up of 6 years. Compared to women with T2DM but no history of GDM or GHTD, women with T2DM and a history of GDM or GHTD exhibited higher incident CVD (adjusted hazard ratio [aHR]: 1.19, 95% CI: 1.01, 1.41) and CAD (aHR: 1.35, 95% CI: 1.10, 1.66) risks. They also had higher CVD (aHR: 3.70, 95% CI: 2.79, 4.91), CAD (aHR: 4.96, 95% CI: 3.43, 7.19), cerebrovascular disease (aHR: 2.41, 95% CI: 1.54, 3.76) and HF (aHR: 4.95, 95% CI: 2.05, 11.94) risks versus women without T2DM and no history of GDM or GHTD. However, they had lower CVD, CAD, cerebrovascular disease and HF risks, compared to men with T2DM.
Among women with T2DM, prior GDM or GHTD conferred a higher CVD risk.
Authors
Echouffo-Tcheugui Echouffo-Tcheugui, McCormack McCormack, Ke Ke, Retnakaran Retnakaran, Shah Shah
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