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This research aims to demonstrate and explain a meticulous care plan applicable to Mycoplasma pneumonia (MP) in children. This plan integrates multi-dimensional measures such as psychological care, respiratory tract management, dietary guidance, fever care and health education, forming a structured care path. A total of 122 children with MP admitted from May to September 2023 were selected for the study. They were divided into the experimental group and the control group by random number table method, with 61 cases in each group. The control group received routine care, while the experimental group received meticulous care on the basis of routine care. The plan mainly describes the story-telling communication skills in psychological care, the standard operation of nebulization inhalation parameters and back tapping in respiratory care, the hierarchical monitoring and treatment of fever, as well as the modular health education content for caregivers. The results show that meticulous care can promote symptom relief in children, reduce inflammatory indicators, enhance disease awareness and nursing satisfaction, verifying the feasibility and positive role of this nursing plan in clinical practice. This study provides a replicable and scalable operational framework for the systematic care of MP in children.