Association Between Serum Follicle-Stimulating Hormone Levels and Risk of Diabetes in Middle-Aged Men: A Long-Term Population-Based Longitudinal Study.
This study aimed to investigate the association between serum FSH levels and both the prevalence and incidence of T2DM among middle-aged and older men.
This study utilised data from 1097 men aged ≥ 40 years, who participated in the population-based Tehran Lipid and Glucose Study. Participants were followed over six phases between 2002 and 2021. FSH levels were measured at baseline, and participants were followed for incident T2DM over 3774.78 person-years. Multivariable logistic and Cox regression models were used to examine associations between FSH levels and prevalent and incident T2DM, adjusting for demographic and metabolic confounders. Subgroup analyses were performed by age group (< 50 vs. ≥ 50 years).
At baseline, the prevalence of T2DM was 18.41%, and no significant association was observed between FSH levels and T2DM prevalence after full adjustment (OR: 1.0; 95% CI: 0.98-1.03). During follow-up, 302 new T2DM cases were identified. In the fully adjusted Cox model, higher FSH levels were independently associated with a lower risk of developing T2DM (HR: 0.96; 95% CI: 0.93-0.99). The inverse association was especially evident in men aged ≥ 50 years (HR: 0.96; 95% CI: 0.93-0.99), whereas no significant association was found in younger men.
Higher serum FSH levels were independently associated with a reduced risk of incident T2DM in men, particularly among those aged ≥ 50. These findings suggest a potential protective metabolic role of FSH in older men. Further research is warranted to elucidate the non-reproductive roles of FSH in men.
This study utilised data from 1097 men aged ≥ 40 years, who participated in the population-based Tehran Lipid and Glucose Study. Participants were followed over six phases between 2002 and 2021. FSH levels were measured at baseline, and participants were followed for incident T2DM over 3774.78 person-years. Multivariable logistic and Cox regression models were used to examine associations between FSH levels and prevalent and incident T2DM, adjusting for demographic and metabolic confounders. Subgroup analyses were performed by age group (< 50 vs. ≥ 50 years).
At baseline, the prevalence of T2DM was 18.41%, and no significant association was observed between FSH levels and T2DM prevalence after full adjustment (OR: 1.0; 95% CI: 0.98-1.03). During follow-up, 302 new T2DM cases were identified. In the fully adjusted Cox model, higher FSH levels were independently associated with a lower risk of developing T2DM (HR: 0.96; 95% CI: 0.93-0.99). The inverse association was especially evident in men aged ≥ 50 years (HR: 0.96; 95% CI: 0.93-0.99), whereas no significant association was found in younger men.
Higher serum FSH levels were independently associated with a reduced risk of incident T2DM in men, particularly among those aged ≥ 50. These findings suggest a potential protective metabolic role of FSH in older men. Further research is warranted to elucidate the non-reproductive roles of FSH in men.
Authors
Mousavi Mousavi, Firouzi Firouzi, Ramezani Tehrani Ramezani Tehrani, Azizi Azizi, Behboudi-Gandevani Behboudi-Gandevani
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