Association of Combined TyG-BMI and hs-CRP With Incident Cardiovascular Disease in an Aging Chinese Population: A Nationwide Prospective Cohort Study.
Cardiovascular diseases (CVD) are a leading cause of global mortality and disability, with insulin resistance and inflammation indicated by high-sensitivity C-reactive protein (hs-CRP) as key risk factors.
Data from 9,190 participants in a nationwide health and retirement longitudinal study were analyzed. Participants with missing data or a history of stroke or heart disease at baseline were excluded. Baseline TyG-BMI and hs-CRP were measured. CVD events (based on self-reported physician diagnoses) were assessed using standardized surveys. Cox proportional hazards models were applied to evaluate the association of combined TyG-BMI and hs-CRP levels with incident CVD, adjusting for covariates. The reference group comprised participants with TyG-BMI below the median and hs-CRP <1 mg/L.
The presence of elevated TyG-BMI and hs-CRP levels was significantly associated with an increased risk of CVD, with an adjusted hazard ratio (aHR) of 1.215 (95% CI 1.085-1.362). The risk was particularly pronounced in the age group of 45 to 59 years, with an aHR of 1.325 (95% CI 1.131-1.552) for cardiovascular diseases and 1.687 (95% CI 1.143-2.490) for stroke in the 60 to 69 years age group. The study also indicated a nonlinear correlation between TyG-BMI and incident CVD, and a linear correlation for hs-CRP.
The combined elevation of baseline TyG-BMI and hs-CRP is associated with higher incident CVD risk in an aging Chinese population, particularly in middle-aged and older adults. These findings suggest that integrating both markers into clinical risk assessment may help refine cardiovascular risk stratification, pending further validation in independent cohorts.
Data from 9,190 participants in a nationwide health and retirement longitudinal study were analyzed. Participants with missing data or a history of stroke or heart disease at baseline were excluded. Baseline TyG-BMI and hs-CRP were measured. CVD events (based on self-reported physician diagnoses) were assessed using standardized surveys. Cox proportional hazards models were applied to evaluate the association of combined TyG-BMI and hs-CRP levels with incident CVD, adjusting for covariates. The reference group comprised participants with TyG-BMI below the median and hs-CRP <1 mg/L.
The presence of elevated TyG-BMI and hs-CRP levels was significantly associated with an increased risk of CVD, with an adjusted hazard ratio (aHR) of 1.215 (95% CI 1.085-1.362). The risk was particularly pronounced in the age group of 45 to 59 years, with an aHR of 1.325 (95% CI 1.131-1.552) for cardiovascular diseases and 1.687 (95% CI 1.143-2.490) for stroke in the 60 to 69 years age group. The study also indicated a nonlinear correlation between TyG-BMI and incident CVD, and a linear correlation for hs-CRP.
The combined elevation of baseline TyG-BMI and hs-CRP is associated with higher incident CVD risk in an aging Chinese population, particularly in middle-aged and older adults. These findings suggest that integrating both markers into clinical risk assessment may help refine cardiovascular risk stratification, pending further validation in independent cohorts.