Association of Left Ventricular Mass with Hospital Length of Stay and Glucose Infusion Needs in Infants of Diabetic Mothers.
We aimed to assess the relationship between postnatal left ventricular mass (LVM) z-score and clinical outcomes among infants of diabetic mothers (IDMs).
We performed a retrospective cohort study of infants born to mothers with pregestational diabetes mellitus. The primary predictor was postnatal LVM z-score; the primary outcome was hospital length of stay (LOS). A secondary outcome was maximum glucose infusion rate (GIR) during hospitalization.
There were 112 infants who met the inclusion criteria (52% male). After multiple linear regression, there was a weak relationship between LVM z-score and LOS (R2 = 0.055; p = 0.002); the relationship between LVM z-score and maximum GIR was somewhat stronger (R2 = 0.205, p < 0.001).
LVM measured by echocardiography during the first week of life is weakly but independently associated with total LOS and maximum GIR among infants born to mothers with pregestational diabetes mellitus. The impact of left ventricular hypertrophy in IDMs on clinical outcomes should be considered in clinical context.
· Increased LVM is marginally associated with longer LOS in IDMs.. · Elevated LVM is linked to higher maximum GIR in IDMs.. · Higher LVM may reflect illness severity in IDMs..
We performed a retrospective cohort study of infants born to mothers with pregestational diabetes mellitus. The primary predictor was postnatal LVM z-score; the primary outcome was hospital length of stay (LOS). A secondary outcome was maximum glucose infusion rate (GIR) during hospitalization.
There were 112 infants who met the inclusion criteria (52% male). After multiple linear regression, there was a weak relationship between LVM z-score and LOS (R2 = 0.055; p = 0.002); the relationship between LVM z-score and maximum GIR was somewhat stronger (R2 = 0.205, p < 0.001).
LVM measured by echocardiography during the first week of life is weakly but independently associated with total LOS and maximum GIR among infants born to mothers with pregestational diabetes mellitus. The impact of left ventricular hypertrophy in IDMs on clinical outcomes should be considered in clinical context.
· Increased LVM is marginally associated with longer LOS in IDMs.. · Elevated LVM is linked to higher maximum GIR in IDMs.. · Higher LVM may reflect illness severity in IDMs..
Authors
Kannan Kannan, Spray Spray, Theisen Theisen, Daily Daily, Rumpel Rumpel, Dajani Dajani, Bolin Bolin
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