Clinical Guidance on the Safe Use of Glucagon-like Peptide-1 Receptor Agonists in Adults with Type 1 Diabetes.
This article provides a stepwise guidance on the safe use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) as adjunctive therapy in adults with type 1 diabetes (T1D). Here, we first identify the phenotypes within T1D most likely to benefit and then outline best practices for GLP-1RA initiation and titration. We dive into details on the components of patient education and counseling, best practices for monitoring, strategies to mitigate adverse effects and a practical framework for insulin dose adjustments to provide individualized care in adults with T1D. We additionally provide a one-page, provider-facing checklist to support safe, patient-centered implementation in clinical practice.