Cutaneous melanoma histopathologic features and laboratory findings as predictors of sentinel lymph node status and progression-free survival: a single-center experience.
Cutaneous melanoma (CM) is the most aggressive cutaneous malignancy. The aim of the study was to determine the predictive value of primary tumor histopathologic features and laboratory findings used in routine CM follow-up for sentinel lymph node biopsy (SLNB) results and progression-free survival (PFS).
This retrospective study included 157 patients. Planar images were acquired after an intradermal injection of 18 to 30 MBq of 99mTc-nanocolloid in 0.3 ml at two to eight sites 5 to 10 mm from the surgical scar. SLN excision was performed a day after lymphoscintigraphy.
In a logistic regression analysis, Breslow thickness, ulceration status, and mitotic rate showed possible predictive significance for SLNB results, with serum lactate dehydrogenase (LDH) being the only independent predictor (p = 0.042). The difference in survival distributions reached statistical significance for Breslow thickness, mitotic rate, and LDH (p < 0.05, Kaplan-Meier, log-rank test). In a Cox regression analysis, Breslow thickness was a possible predictor of PFS and mitotic rate was an independent predictor (p = 0.025).
LDH is an independent predictor of SLN histopathology findings, and mitotic rate is an independent predictor of PFS.
This retrospective study included 157 patients. Planar images were acquired after an intradermal injection of 18 to 30 MBq of 99mTc-nanocolloid in 0.3 ml at two to eight sites 5 to 10 mm from the surgical scar. SLN excision was performed a day after lymphoscintigraphy.
In a logistic regression analysis, Breslow thickness, ulceration status, and mitotic rate showed possible predictive significance for SLNB results, with serum lactate dehydrogenase (LDH) being the only independent predictor (p = 0.042). The difference in survival distributions reached statistical significance for Breslow thickness, mitotic rate, and LDH (p < 0.05, Kaplan-Meier, log-rank test). In a Cox regression analysis, Breslow thickness was a possible predictor of PFS and mitotic rate was an independent predictor (p = 0.025).
LDH is an independent predictor of SLN histopathology findings, and mitotic rate is an independent predictor of PFS.
Authors
Pantić Pantić, Pantović Pantović, Kotur Kotur, Petričević Petričević, Radivojević Radivojević, Petrović Petrović, Vujošević Vujošević, Grujičić Grujičić, Grozdić Milojević Grozdić Milojević, Šobić Šaranović Šobić Šaranović, Artiko Artiko, Odalović Odalović
View on Pubmed