Demographic and Clinical Correlates of Body Mass Index in Older Age Bipolar Disorder: Results from the GAGE-BD Project.

Background and Objectives: There are known associations between bipolar disorder and obesity, but it has not been well characterized in older adults with bipolar disorder (OABD). This study aims to examine body mass index (BMI) and its clinical correlations in OABD. Materials and Methods: A secondary analysis was conducted using data from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) project, an international harmonized dataset of OABD cohorts. To examine the relationship between BMI and clinical characteristics (e.g., sex, psychiatric history, symptom severity, medication use, comorbidities), multivariable linear regression and multinomial logistic regression models with random effect for study cohort were used, with BMI as a continuous and as an ordinal (underweight vs. healthy weight vs. overweight vs. obese) dependent variable, respectively. Results: Of 1,226 OABD participants with BMI data, 405 (33.0%) were classified as overweight (BMI 25-29.99) and 462 (37.7%) as obese (BMI > 30). In linear regression models, higher BMI was associated with younger age, higher number of somatic comorbidities, and anticonvulsant use, while lower BMI was associated with lithium use. In logistic regression models, obesity was associated with cardiovascular comorbidity, musculoskeletal comorbidity and endocrine comorbidity. Conclusions: A high proportion of individuals with OABD are overweight or obese. Several demographic and clinical correlations of higher BMI were found, including younger age, higher number of medical comorbidities and anticonvulsant use. Clinicians should monitor and manage weight changes and associated comorbidities, and promote lifestyle and health interventions to minimize the risk of negative health outcomes associated with high BMI.
Mental Health
Access
Care/Management
Advocacy

Authors

Chan Chan, Rothenberg Rothenberg, Briggs Briggs, Mallu Mallu, Fiorelli Fiorelli, Almeida Almeida, Altınbaş Altınbaş, Balanzá-Martinez Balanzá-Martinez, Barbosa Barbosa, Blumberg Blumberg, Chen Chen, Flicker Flicker, Gildengers Gildengers, Haarman Haarman, Klaus Klaus, Lafer Lafer, Nunes Nunes, Olagunju Olagunju, Oluwaniyi Oluwaniyi, Orhan Orhan, Patrick Patrick, Pomarol-Clotet Pomarol-Clotet, Radua Radua, Rej Rej, Saores Saores, Teixeira Teixeira, Tsai Tsai, Vidal-Rubio Vidal-Rubio, Vieta Vieta, Weisenbach Weisenbach, Eyler Eyler, Dols Dols, Sajatovic Sajatovic
View on Pubmed
Share
Facebook
X (Twitter)
Bluesky
Linkedin
Copy to clipboard