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With increasing life-expectancy, the older population of Nepal has also been increasing with Nepal census 2021 reporting 60 years and above population to be 10.21%. Nepal also has a high migration rate with 2.2 million absentee population reported in the 2021 census. Outmigration of adult children can negatively impact parental health, including loneliness, depression, and poor psychological health, despite potentially increasing parents' financial resources and access to welfare services. This study aims to evaluate the level of depression and their associated factors among the empty nest older population residing in ward number 9 of Kathmandu Metropolitan City after adult children's migration. A cross-sectional mixed-method study was carried out among 140 older parents aged over 60, with all children migrated abroad, selected randomly from a social security list. Depression was measured using Geriatric Depression Scale and regression analysis was performed. Qualitative part included 21 in-depth interviews analyzed thematically and triangulated with quantitative data. The study revealed that nearly half of empty nesters had depression, with 30% mild and 5% severe. The study identified that single (widowed, divorced or separated) parents had 28.3 times higher cumulative odds of being in a higher category of depressive symptoms, i.e., "moderate/severe and mild" versus "mild and normal" compared to those who are married and living together with their spouses holding constant all other variables. Qualitative interviews supported these findings, highlighting depression among older, widowed parents. The empty nest older population are at increased risk of suffering from depression. Due to the limited evidence, this study investigates if adult children's migration affects the mental health of older parents in Nepal, specifically aiming to understand depression among them and inform policies for their better psychological well-being.