Dysfunctional brain circuits overlap in lesional and idiopathic obsessive-compulsive disorder.
Obsessive-compulsive disorder (OCD) may develop following brain lesions, but lesion distribution and connectivity patterns are unknown.
Cases of OCD associated with focal brain lesions were identified using a systematic literature search and compared to control lesions (N=608). Connectivity with each lesion location was computed using normative functional connectivity (N=1000) and a network specific to OCD lesions was identified. The relevance of this network for primary OCD was explored.
Among 129 cases of lesion-associated OCD, 40 had clearly defined locations. OCD-associated lesions intersected the orbitofrontal cortex and right temporal pole more than control lesions and were associated with connectivity to a distinct brain network. This network overlapped with abnormal functional brain imaging and with effective brain stimulation targets in primary OCD.
Lesion locations associated with OCD map to a common brain network that aligns with brain imaging abnormalities and brain stimulation outcomes in patients with primary OCD.
Cases of OCD associated with focal brain lesions were identified using a systematic literature search and compared to control lesions (N=608). Connectivity with each lesion location was computed using normative functional connectivity (N=1000) and a network specific to OCD lesions was identified. The relevance of this network for primary OCD was explored.
Among 129 cases of lesion-associated OCD, 40 had clearly defined locations. OCD-associated lesions intersected the orbitofrontal cortex and right temporal pole more than control lesions and were associated with connectivity to a distinct brain network. This network overlapped with abnormal functional brain imaging and with effective brain stimulation targets in primary OCD.
Lesion locations associated with OCD map to a common brain network that aligns with brain imaging abnormalities and brain stimulation outcomes in patients with primary OCD.
Authors
Cotovio Cotovio, Descalço Descalço, Caballero-Insaurriaga Caballero-Insaurriaga, Martins Martins, Faro Viana Faro Viana, Fonseca Fonseca, Ramos Ramos, Santos Santos, Maia Maia, Oliveira Oliveira, Loução Loução, Barbour Barbour, Siddiqi Siddiqi, Fox Fox, Barahona-CorrĂȘa Barahona-CorrĂȘa, Oliveira-Maia Oliveira-Maia
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