Early-treated children with perinatal HIV show elevated monocyte activation into late childhood.
Early ART initiation in children with perinatal HIV (CHIV) greatly improves long-term outcomes. However, little is known of the long-term inflammatory profile. Our longitudinal study compared 26 inflammatory markers in early treated CHIV and HIV-unexposed children. CHIV displayed extensive immune marker elevations, clustered around monocyte activation. Despite early-antiretroviral therapy and sustained viral suppression, these children are at increased risk of non-communicable diseases.
Authors
Davies Davies, Webber Webber, Dirajlal-Fargo Dirajlal-Fargo, Funderburg Funderburg, Bouic Bouic, Otwombe Otwombe, Cotton Cotton, Browne Browne, Innes Innes, Vaida Vaida
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