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Polyendocrine metabolic ovarian syndrome (PMOS), formerly known as polycystic ovary syndrome, is a common complex endocrinopathy affecting the reproductive, metabolic, and psychosocial health of females of reproductive age. A 26-year-old woman with PMOS and infertility (7-year duration) underwent multiple cycles of ovulation induction, intrauterine insemination, and in vitro fertilization. Following a 12-week structured yoga program (postures, breathwork, meditation), hormonal and metabolic parameters normalized and oxidative stress and inflammation decreased significantly. We saw significant improvement in mitochondrial integrity, reduced severity of comorbid depression, and improved quality of life. On follow-up, the participant was found to have conceived within 20 weeks of practice and delivered a healthy baby. This case highlights the role of yoga in the management of PMOS, adding evidence of yoga's benefit at the cellular and molecular level and clinical improvement. Regular yoga practice has the potential to serve as a holistic, nonpharmacological approach for managing PMOS and associated comorbidities.