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To improve the clinical efficacy and quality of perioperative care for patients with liver cancer undergoing Yttrium-90 selective internal radiation therapy (⁹⁰Y-SIRT) and to standardize perioperative management and radiation safety practices, experts from relevant fields in China, led by the Tumor Interstitial Implantation Therapy Professional Committee of the Chinese Anti-Cancer Association and the Interventional Therapy Quality Control Center of Shanghai, developed this expert consensus on the perioperative management based on the clinical application and experience of ⁹⁰Y-SIRT in China, together with relevant domestic literature. The final consensus covers patient selection and treatment decision-making for ⁹⁰Y-SIRT, radiation protection and safety management, perioperative stratified management strategies, and discharge preparation and follow-up management. This consensus provides guidance and a practical framework for the perioperative management of patients undergoing ⁹⁰Y-SIRT.