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Massive hemoptysis and postpneumonectomy acute respiratory distress syndrome (ARDS) are rare but life-threatening conditions with limited therapeutic options. This case highlights the feasibility of combining venovenous extracorporeal membrane oxygenation (VV-ECMO) with esophageal pressure-guided ventilation to support both surgical and respiratory management in a critically ill patient.

A 67-year-old woman developed massive hemoptysis after bronchoscopic biopsy of a left hilar lung mass. Despite bronchial artery embolization and selective right lung ventilation, severe ARDS ensued. A salvage left pneumonectomy was performed under VV-ECMO due to refractory bleeding. Postoperatively, the patient developed right-lung ARDS with total airway closure and high elastance. Esophageal pressure monitoring enabled safe adjustment of ventilator settings. She was weaned from ECMO on postoperative day 16 and later discharged from ICU. Final pathology confirmed an atypical carcinoid tumor with negative margins.

VV-ECMO can enable life-saving pneumonectomy in select patients. Esophageal pressure monitoring may optimize ventilation in postpneumonectomy ARDS with severe mechanical impairment.