Image-Based Meta- and Mega-Analysis (IBMMA): A Unified Framework for Large-Scale, Multi-Site, Neuroimaging Data Analysis.
The increasing scale and complexity of neuroimaging datasets aggregated from multiple study sites present substantial analytic challenges, as existing statistical analysis tools struggle to handle missing voxel-data, suffer from limited computational speed and inefficient memory allocation, and are restricted in the types of statistical designs they are able to model. We introduce Image-Based Meta- & Mega-Analysis (IBMMA), a novel software package implemented in R and Python that provides a unified framework for analyzing diverse neuroimaging features, efficiently handles large-scale datasets through parallel processing, offers flexible statistical modeling options, and properly manages missing voxel-data commonly encountered in multi-site studies. IBMMA successfully analyzed a large-n dataset of several thousand participants and revealed findings in brain regions that some traditional software overlooked due to missing voxel-data resulting in gaps in brain coverage. IBMMA has the potential to accelerate discoveries in neuroscience and enhance the clinical utility of neuroimaging findings.
Authors
Steele Steele, Huggins Huggins, Morey Morey, Hussain Hussain, Russell Russell, Suarez-Jimenez Suarez-Jimenez, Pozzi Pozzi, Jameei Jameei, Schmaal Schmaal, Veer Veer, Waller Waller, Jahanshad Jahanshad, Thomopoulos Thomopoulos, Salminen Salminen, Olff Olff, Frijling Frijling, Veltman Veltman, Koch Koch, Nawijn Nawijn, van Zuiden van Zuiden, Wang Wang, Zhu Zhu, Li Li, Stein Stein, Ipser Ipser, Neria Neria, Zhu Zhu, Ravid Ravid, Zilcha-Mano Zilcha-Mano, Lazarov Lazarov, Stevens Stevens, Ressler Ressler, Jovanovic Jovanovic, van Rooij van Rooij, Fani Fani, Mueller Mueller, Hudson Hudson, Daniels Daniels, Sierk Sierk, Manthey Manthey, Walter Walter, van der Wee van der Wee, van der Werff van der Werff, Vermeiren Vermeiren, Schmahl Schmahl, Herzog Herzog, Rektor Rektor, Říha Říha, Kaufman Kaufman, Lebois Lebois, Baker Baker, Rosso Rosso, Olson Olson, King King, Liberzon Liberzon, Angstadt Angstadt, Davenport Davenport, Disner Disner, Sponheim Sponheim, Straube Straube, Hofmann Hofmann, Lu Lu, Qi Qi, Wang Wang, Kunch Kunch, Xie Xie, Quidé Quidé, El-Hage El-Hage, Lissek Lissek, Berg Berg, Bruce Bruce, Cisler Cisler, Ross Ross, Herringa Herringa, Grupe Grupe, Nitschke Nitschke, Davidson Davidson, Larson Larson, deRoon-Cassini deRoon-Cassini, Tomas Tomas, Fitzgerald Fitzgerald, Elman Elman, Panizzon Panizzon, Franz Franz, Lyons Lyons, Kremen Kremen, Feola Feola, Blackford Blackford, Olatunji Olatunji, May May, Nelson Nelson, Gordon Gordon, Abdallah Abdallah, Lanius Lanius, Densmore Densmore, Théberge Théberge, Neufeld Neufeld, Thompson Thompson, Sun Sun
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