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Brain tumors significantly disrupt brain network organization, yet the temporal dynamics of network reorganization following surgical intervention remain poorly understood. This study investigated longitudinal changes in functional brain network properties across pre-surgical, post-surgical, and follow-up time points in glioma patients. Using graph theory analysis of resting-state functional magnetic resonance imaging (fMRI) data, we examined whole-brain network metrics as well as the connections involving perilesional and contralesional regions. Results revealed significant alterations in network topology over time, with distinct patterns of reorganization in perilesional and contralesional regions, suggesting mechanisms of plasticity and recovery in brain network architecture following tumor resection.Clinical Relevance-These findings have significant implications for surgical planning and post-operative care, suggesting the need for therapeutic approaches that consider both local and distant network effects. The demonstrated importance of contralesional adaptation particularly warrants attention in rehabilitation strategies, potentially opening new avenues for targeted interventions in recovery.