Malignant Odontogenic Tumors: A Clinicopathological Study of 53 Cases in Brazil.
This study aimed to investigate the clinicopathological features of malignant odontogenic tumors (MOTs) and to provide a comprehensive characterization that enhances the current understanding of this disease group.
MOTs were retrieved from six Brazilian oral pathology services between 2007 and 2025. Demographic, clinical and radiographic data were collected from the charts, and the histological H&E-stained sections were revised by two blinded pathologists; previously available immunohistochemical and molecular findings were retrieved and reviewed in selected cases and the diagnosis was established according to the 2022 World Health Organization classification.
A total of 53 malignant odontogenic tumors were identified, predominantly affecting the mandible (83%), with a slight male predominance (male-to-female ratio, 1.12:1) and a mean age of 41.4 years. Ameloblastic carcinoma was the most frequent subtype (58.5%), followed by clear cell odontogenic carcinoma (18.9%), ameloblastic fibrosarcoma (13.2%), primary intraosseous carcinoma (7.5%), and ghost cell odontogenic carcinoma (1.9%).
This multicenter review summarizes the main features of malignant odontogenic tumors. Although rare, these tumors often exhibit locally aggressive behavior, highlighting the need for early diagnosis, accurate histopathological evaluation, and standardized reporting with long-term follow-up.
MOTs were retrieved from six Brazilian oral pathology services between 2007 and 2025. Demographic, clinical and radiographic data were collected from the charts, and the histological H&E-stained sections were revised by two blinded pathologists; previously available immunohistochemical and molecular findings were retrieved and reviewed in selected cases and the diagnosis was established according to the 2022 World Health Organization classification.
A total of 53 malignant odontogenic tumors were identified, predominantly affecting the mandible (83%), with a slight male predominance (male-to-female ratio, 1.12:1) and a mean age of 41.4 years. Ameloblastic carcinoma was the most frequent subtype (58.5%), followed by clear cell odontogenic carcinoma (18.9%), ameloblastic fibrosarcoma (13.2%), primary intraosseous carcinoma (7.5%), and ghost cell odontogenic carcinoma (1.9%).
This multicenter review summarizes the main features of malignant odontogenic tumors. Although rare, these tumors often exhibit locally aggressive behavior, highlighting the need for early diagnosis, accurate histopathological evaluation, and standardized reporting with long-term follow-up.
Authors
Paula de Paula Paula de Paula, Pontes Pontes, Fonseca Fonseca, Vargas Vargas, Lopes Lopes, Dos Santos Silva Dos Santos Silva, Júnior Júnior, Penafort Penafort, Mosqueda-Taylor Mosqueda-Taylor, da Silva Santos da Silva Santos, Lara Lara, Soares Soares, Dos Santos Pinto Júnior Dos Santos Pinto Júnior, Ribeiro Ribeiro, de Mendonça de Mendonça, Arantes Arantes, Vencio Vencio, de Jesus Costa de Jesus Costa, de Aquino Xavier de Aquino Xavier, Dos Santos Dos Santos, Gondak Gondak, Siqueira Siqueira, Schussel Schussel, de Lima de Lima, Soares Soares, Pontes Pontes
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