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Diaphyseal nonunions after bone tumor resection present a significant reconstructive challenge. We report a 39-year-old woman who developed a diaphyseal humeral nonunion after giant cell tumor resection and reconstruction with vascularized fibula graft. She presented with symptomatic segmental bone loss and hardware failure. Two-stage Masquelet-induced membrane procedure was performed, resulting in complete union and excellent functional recovery at 12 months postoperatively.

This case highlights the potential of the Masquelet technique in reconstruction of refractory nonunions despite previous failed reconstructive attempts.