Molecular Methods: Analytical Principles and Test Design Considerations.
In this article, the authors review the types of molecular alterations present in cancer and molecular methods used commonly in clinical diagnostic laboratories, including technologies such as next-generation sequencing and digital polymerase chain reaction. Additionally, the authors discuss considerations for test design, incorporating factors such as specimen type and biomarker type, to design a molecular test menu that delivers accurate and timely results in an efficient and cost-effective manner.