Molecular Pathology of Endocrine Gland Tumors.
Endocrine gland tumors are characterized by a wide spectrum of pathologic, clinical, and molecular features. Next-generation sequencing technologies have greatly improved our knowledge of this group of neoplasms, showing robust genotype-phenotype correlation. This review summarizes the main molecular changes found in endocrine gland tumors, highlighting the interplay between tumor-specific somatic or germline genetic changes, pathology, and clinical features. The aim of the article is to provide essential information about the role of molecular pathology in defining diagnosis, prognosis, and identification of biomarkers for molecular targeted therapy.