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Head and neck cancers and their treatments result in functional, nutritional, and psychosocial sequelae that remain insufficiently integrated into conventional oncological follow-up. Systematic integration of standardized functional assessments and Patient-Reported Outcome Measures facilitates early identification of patients' needs, promoting more personalized multidisciplinary approaches. This article reviews the rationale for longitudinal follow-up in head and neck cancer patients, its clinical relevance, actual recommended tools for functional assessment, and practical aspects of its implementation. The experience developed at the HUG illustrates the feasibility of this approach and its potential to improve care coordination, optimize supportive care, and establish a prospective clinical database to support future research.