Osteosarcoma of the Jaws in Latin America: A Retrospective Multicenter Series of 119 Cases.
Epidemiological and survival data on osteosarcoma of the jaws (OSJ) in Latin America remain scarce. We characterized the clinicopathological, radiographic, treatment-related, and survival features of OSJ in Latin America.
This multicenter case series involved 22 institutions from Brazil, Chile, Argentina, Colombia, Venezuela, Uruguay, and Mexico. Demographic, clinical, radiographic, histopathological, treatment, and survival data were analyzed using descriptive and inferential statistical methods. Survival outcomes were assessed using Kaplan-Meier analysis and Cox regression models.
A total of 119 OSJ cases were included. The median age was 33 years, with a female predominance (58%), and the mandible was the most commonly affected site (68.9%). A mixed radiographic appearance predominated and was frequently accompanied by cortical perforation and a sunburst periosteal reaction. Histologically, the osteoblastic subtype accounted for 63.5% of cases. Surgical resection was the main treatment modality (71.2%). Increasing age (p = 0.034) and multimodal or nonsurgical management (p = 0.023) were independently associated with poorer survival. The estimated overall survival rates were 67.5% at 12 months and 37.5% at 60 months.
Data corroborate previous literature and demonstrate that OSJ in Latin America predominantly affects adults and exhibits aggressive patterns. Surgical management remains central to improving survival whenever it is technically feasible.
This multicenter case series involved 22 institutions from Brazil, Chile, Argentina, Colombia, Venezuela, Uruguay, and Mexico. Demographic, clinical, radiographic, histopathological, treatment, and survival data were analyzed using descriptive and inferential statistical methods. Survival outcomes were assessed using Kaplan-Meier analysis and Cox regression models.
A total of 119 OSJ cases were included. The median age was 33 years, with a female predominance (58%), and the mandible was the most commonly affected site (68.9%). A mixed radiographic appearance predominated and was frequently accompanied by cortical perforation and a sunburst periosteal reaction. Histologically, the osteoblastic subtype accounted for 63.5% of cases. Surgical resection was the main treatment modality (71.2%). Increasing age (p = 0.034) and multimodal or nonsurgical management (p = 0.023) were independently associated with poorer survival. The estimated overall survival rates were 67.5% at 12 months and 37.5% at 60 months.
Data corroborate previous literature and demonstrate that OSJ in Latin America predominantly affects adults and exhibits aggressive patterns. Surgical management remains central to improving survival whenever it is technically feasible.
Authors
Drumond Drumond, de Arruda de Arruda, Villaroel-Dorrego Villaroel-Dorrego, Dos Reis Dos Reis, Sampaio Sampaio, Schuch Schuch, Menna-Barreto Menna-Barreto, Martins Martins, Goulart Goulart, Souza Souza, de Souza de Souza, Silva Silva, Cordero-Torres Cordero-Torres, Morales-Espinosa Morales-Espinosa, Panico Panico, Gilligan Gilligan, Garola Garola, Cerullo Cerullo, Leonardi Leonardi, Giménez Giménez, Flück Flück, Castrillo Castrillo, Leguina Leguina, Peña-Vega Peña-Vega, Rodríguez-Mora Rodríguez-Mora, Mezzomo-Faccin Mezzomo-Faccin, de Albuquerque-Junior de Albuquerque-Junior, Gondak Gondak, Israel Israel, Alves Alves, Gomes Gomes, Nonaka Nonaka, Ribeiro Ribeiro, de Mendonça de Mendonça, Moreira Moreira, Arantes Arantes, Cavalcante Cavalcante, Turatti Turatti, Cavalcante Cavalcante, Tacchi Tacchi, Gomes Gomes, Bubolz Bubolz, Etges Etges, Umpiérrez Umpiérrez, Cueto Cueto, Beovide-Cortegoso Beovide-Cortegoso, Bologna-Molina Bologna-Molina, Aranda-Romo Aranda-Romo, Tejeda-Nava Tejeda-Nava, Abreu Abreu, de Andrade de Andrade, Mesquita Mesquita
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