Ovarian cancer and multimodal prehabilitation options - a case study.
The aim of this case report is to present the impact of multimodal prehabilitation on the quality of life, cognitive performance, physical fitness, and nutritional status in a patient with advanced ovarian cancer.
A 74-year-old woman with high grade serous ovarian carcinoma pT3bN1a was scheduled for radical surgery following three cycles of neoadjuvant chemotherapy. She underwent a three-week intensive multimodal prehabilitation program in a 4/7 regimen involving physiotherapy, occupational therapy, nutritional counselling, psychological support, and supervision by a rehabilitation physician. The effect was evaluated using functional and cognitive tests, stress and disability scales, and body composition analysis (InBody).
Improvement was observed across all major domains: reduction in disability (WHODAS 20 ® 5%), enhancement of cognitive function (MoCA 22 ® 25), decreased perceived stress (PSS-10 17 ® 11), reduction in frailty (FI 3 ® 1), and restoration of full independence in activities of daily living (Katz Index 6/6). Physical performance showed marked gains (6MWT +42 m, 5×SST -6.5 s, handgrip strength +4 kg), while pulmonary function tests confirmed improved ventilatory capacity (FVC, FEV1, PEF). Nutritional assessment indicated a reduced risk of malnutrition according to the MUST screening tool, although bioimpedance analysis demonstrated a mild increase in total body fat and visceral adipose tissue.
Intensive multimodal prehabilitation positively influenced the patient's psychosensory-motor potential, reduced disability, enhanced perioperative fitness, and confirmed its indispensable role in oncogynecology.
A 74-year-old woman with high grade serous ovarian carcinoma pT3bN1a was scheduled for radical surgery following three cycles of neoadjuvant chemotherapy. She underwent a three-week intensive multimodal prehabilitation program in a 4/7 regimen involving physiotherapy, occupational therapy, nutritional counselling, psychological support, and supervision by a rehabilitation physician. The effect was evaluated using functional and cognitive tests, stress and disability scales, and body composition analysis (InBody).
Improvement was observed across all major domains: reduction in disability (WHODAS 20 ® 5%), enhancement of cognitive function (MoCA 22 ® 25), decreased perceived stress (PSS-10 17 ® 11), reduction in frailty (FI 3 ® 1), and restoration of full independence in activities of daily living (Katz Index 6/6). Physical performance showed marked gains (6MWT +42 m, 5×SST -6.5 s, handgrip strength +4 kg), while pulmonary function tests confirmed improved ventilatory capacity (FVC, FEV1, PEF). Nutritional assessment indicated a reduced risk of malnutrition according to the MUST screening tool, although bioimpedance analysis demonstrated a mild increase in total body fat and visceral adipose tissue.
Intensive multimodal prehabilitation positively influenced the patient's psychosensory-motor potential, reduced disability, enhanced perioperative fitness, and confirmed its indispensable role in oncogynecology.
Authors
Sládková Sládková, Tichá Tichá, Švábenická Švábenická, Kotrbová Kotrbová, Šályová Šályová, Vlastníková Vlastníková, Janatová Janatová, Hoidekrová Hoidekrová, Polková Polková, Zikán Zikán, Brtnický Brtnický
View on Pubmed