Phylogenetic and Mutational Analysis of the Tax Gene in the Human T-Lymphotropic Virus 1 (HTLV-1) in Three Provinces of Iran.
Human T-lymphotropic virus type 1 (HTLV-1) is considered a health issue in Iran. However, its genetic diversity and molecular epidemiologic phylogeny remain poorly characterized.
The Tax gene of 9 asymptomatic individuals across Alborz, Gilan, and Ardabil provinces of Iran was sequenced and analyzed phylogenetically using MEGA-X.
All strains clustered within the Cosmopolitan subtype a, showing high genetic similarity to Japanese and Chinese references. Positive selection (dN/dS > 1) was observed in all samples. Strikingly, the Alborz ISO32 strain exhibited 10 unique nonsynonymous mutations, suggesting regional evolutionary divergence.
This study, as the first multi-provincial study in Iran, reveals the essential requirement for systematic tracking of HTLV-1 genetic diversity and designing prevention programs tailored to each region.
The Tax gene of 9 asymptomatic individuals across Alborz, Gilan, and Ardabil provinces of Iran was sequenced and analyzed phylogenetically using MEGA-X.
All strains clustered within the Cosmopolitan subtype a, showing high genetic similarity to Japanese and Chinese references. Positive selection (dN/dS > 1) was observed in all samples. Strikingly, the Alborz ISO32 strain exhibited 10 unique nonsynonymous mutations, suggesting regional evolutionary divergence.
This study, as the first multi-provincial study in Iran, reveals the essential requirement for systematic tracking of HTLV-1 genetic diversity and designing prevention programs tailored to each region.
Authors
Noori Noori, Shahnavaz Shahnavaz, Bahavar Bahavar, Sharifi Sharifi, Kafialqora Kafialqora, Navi Navi, Foroushani Foroushani, Shafiei Shafiei, Jazayeri Jazayeri, Mozhgani Mozhgani, Norouzi Norouzi
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