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This study examined the association of weekly plant-based medically tailored groceries (MTGs) with cardiovascular-kidney-metabolic outcomes among patients with food insecurity. The intervention began on December 20, 2019, and ended on April 1, 2025 (275 weeks). Linear mixed-effects models estimated the dose-dependent association of MTGs received and the rates of changes in blood pressure, glycated hemoglobin A_1c, weight, and body mass index from baseline to follow-up periods. Among 68 adults, during an average of 2.7 years, each 100 MTGs received was associated with a greater improvement from baseline to follow-up periods in the rates of changes in diastolic blood pressure (-3.21 mm Hg; 95% CI, -4.89 to -1.52), weight (-2.63 kg; 95% CI, -3.73 to -1.53), and body mass index (-1.04 kg/m²; 95% CI, -1.50 to -0.58).