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Borderline personality disorder (BPD) is associated with poor quality of life (QoL), but little is known about which QoL dimensions are affected or what might predict QoL outcomes. Baseline data were collected from 208 participants (aged 15-25 years, with three or more DSM-5 BPD features) in one of three randomized controlled trials conducted at youth mental health services in Melbourne, Australia. Hierarchical regression analyses revealed that BPD severity, avoidant personality disorder diagnosis (AVPD), and psychotic disorder each independently predicted poorer overall QoL. Both BPD severity and AVPD independently predicted all psychosocial subscale dimensions of QoL. For the physical dimensions, AVPD independently predicted pain and senses, whereas BPD severity and psychotic disorder independently predicted independent living. Co-occurring mood or antisocial personality disorder predicted neither overall QoL nor any dimension of QoL. These findings provide additional weight to the argument that young people with BPD should be a high-priority group for early intervention.