[Prolonged air leak after lobectomy and its impact on 30- and 90-day mortality: a retrospective multiple-center study].
To evaluate the impact of PAL on 30- and 90-day mortality and to identify clinical and intraoperative risk factors in patients undergoing anatomical lung resection for malignant tumors.
A retrospective multiple-center study included 700 patients who underwent lobectomy between January 2021 and December 2024. PAL was defined as an air leak persisting beyond 5 postoperative days. Univariable and multivariable logistic regression analysis was performed.
The incidence of PAL was 15.6%. PAL was significantly associated with longer chest drainage duration (median: 16 vs. 7 days), prolonged hospital-stay (21 vs. 11 days) and higher rates of complications TMM grade II-IIIB (p=0.002). Independent risk factors of PAL were low FEV1 (AOR=0.983), thoracotomy (AOR=2.664) and longer surgery time (AOR=1.009; all p<0.001). PAL was not associated with 30-day mortality but was an independent predictor of 90-day mortality (AOR=2.505; p=0.026). Prognostic model for 90-day mortality showed acceptable accuracy (AUC=0.719).
PAL occurred in 15.6% of cases and was associated with prolonged recovery and increased 90-day mortality. Key risk factors were low FEV1, thoracotomy, and longer surgery time.
A retrospective multiple-center study included 700 patients who underwent lobectomy between January 2021 and December 2024. PAL was defined as an air leak persisting beyond 5 postoperative days. Univariable and multivariable logistic regression analysis was performed.
The incidence of PAL was 15.6%. PAL was significantly associated with longer chest drainage duration (median: 16 vs. 7 days), prolonged hospital-stay (21 vs. 11 days) and higher rates of complications TMM grade II-IIIB (p=0.002). Independent risk factors of PAL were low FEV1 (AOR=0.983), thoracotomy (AOR=2.664) and longer surgery time (AOR=1.009; all p<0.001). PAL was not associated with 30-day mortality but was an independent predictor of 90-day mortality (AOR=2.505; p=0.026). Prognostic model for 90-day mortality showed acceptable accuracy (AUC=0.719).
PAL occurred in 15.6% of cases and was associated with prolonged recovery and increased 90-day mortality. Key risk factors were low FEV1, thoracotomy, and longer surgery time.
Authors
Toneev Toneev, Slugin Slugin, Pushkin Pushkin, Shagdaleev Shagdaleev, Martynov Martynov, Rudenko Rudenko, Chernetsov Chernetsov, Ognev Ognev
View on Pubmed