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Cardiac distress is common, yet minimal support is available for nurse assessment of patients. We translated the Cardiac Distress Inventory (CDI) into Thai (CDI-Thai) and evaluated its psychometric properties. This was a cross-sectional study of 250 adults who experienced an acute cardiac event in the past year in southern Thailand. The CDI was translated into Thai using forward-backward translation and expert review. The CDI-Thai achieved translation equivalence to the original version. An eight-factor structure was confirmed by factor analysis, with excellent fit. The CDI-Thai was shown to be culturally relevant and psychometrically robust as a measure of cardiac distress.