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Background: This study aims to psychometrically validate the abbreviated version of the Connor-Davidson Resilience Scale (CD-RISC-10) in Peruvian nurses, evaluating its convergent validity through its association with perceived stress and empathy. Methods: A cross-sectional psychometric study was conducted in 374 Peruvian nurses to evaluate the psychometric properties of CD-RISC-10 through confirmatory factor analysis (CFA). Furthermore, concurrent validity was assessed through correlational analysis using Spearman's rho coefficient to evaluate the relationships among resilience, perceived stress, and empathy. Results: The CFA supported the predominantly one-dimensional model showing an adequate fit when the residual covariance between Items 4 and 7 was specified after correlating the residuals of Items 4 and 7 (CFI = 0.978, TLI = 0.971, RMSEA = 0.080, and SRMR = 0.044). Ordinal Cronbach's alpha of 0.89 and McDonald's omega of 0.81 were obtained. Concurrent validity showed significant correlations with perceived stress (rho = -0.53, p < 0.001) and empathy (rho = 0.31, p < 0.001). Conclusions: The CD-RISC-10 has adequate psychometric properties in Peruvian nurses. Future studies are needed to evaluate its factorial invariance between clinical specialties and establish normative thresholds.