Risk factors for intraoperative floppy iris syndrome in female cataract patients: The roles of ARB medication and diabetes mellitus.
Intraoperative Floppy Iris Syndrome (IFIS) is an intraoperative event observed during cataract surgery, characterized by iris billowing, progressive miosis, and iris prolapse. While prior studies have focused on male patients and α-adrenergic antagonists, risk factors for IFIS in females remain unclear. This study aimed to identify independent risk factors for IFIS in female cataract patients.
Female patients undergoing cataract surgery at Shanghai General Hospital from 2022 to 2024 were included. A total of 298 patients were enrolled in a cross-sectional study, and 416 in a cohort study. IFIS was assessed via surgical video, and logistic regression was used to identify risk factors, which were validated in the cohort.
In the cross-sectional analysis, diabetes mellitus (DM) (OR=14.471, 95% CI: 2.183-95.929, P=0.006) and angiotensin II receptor blocker (ARB) use (OR=1.672, 95% CI: 1.057-26.774, P=0.043) were significantly associated with IFIS. In the cohort study, DM (P=0.023) and ARB use (P=0.039) remained independent risk factors.
Diabetes and ARB medication are independent risk factors for IFIS in female cataract patients. Preoperative identification of these factors may help reduce intraoperative complications and improve surgical safety.
Female patients undergoing cataract surgery at Shanghai General Hospital from 2022 to 2024 were included. A total of 298 patients were enrolled in a cross-sectional study, and 416 in a cohort study. IFIS was assessed via surgical video, and logistic regression was used to identify risk factors, which were validated in the cohort.
In the cross-sectional analysis, diabetes mellitus (DM) (OR=14.471, 95% CI: 2.183-95.929, P=0.006) and angiotensin II receptor blocker (ARB) use (OR=1.672, 95% CI: 1.057-26.774, P=0.043) were significantly associated with IFIS. In the cohort study, DM (P=0.023) and ARB use (P=0.039) remained independent risk factors.
Diabetes and ARB medication are independent risk factors for IFIS in female cataract patients. Preoperative identification of these factors may help reduce intraoperative complications and improve surgical safety.
Authors
Wu Wu, Cui Cui, He He, Jin Jin, Miao Miao, Ma Ma, Sun Sun, Zhu Zhu, Li Li, Zheng Zheng, Yu Yu, Jin Jin, Zou Zou
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