Feed

PANoptosis is a novel and unique form of programmed cell death associated with innate immune responses, which is primarily regulated by the aggregation and activation of the PANoptosome, and exhibits characteristics of apoptosis, pyroptosis and necroptosis. Therefore, the PANoptosome complex has become a key target for preventing this type of cell death. PANoptosis is considered to have a role in infectious diseases and cancer; however, to the best of our knowledge, its role in gastric mucosal diseases has not been comprehensively explored. With the advancement of research on the mechanisms underlying gastric mucosal diseases, a shared regulation and crosstalk among pyroptosis, apoptosis and necroptosis has been suggested to exist during the development and progression of these diseases. The present review briefly introduces the relevant mechanisms and features of PANoptosis, with a focus on its role in gastric mucosal diseases (such as acute gastric mucosal injury, infectious gastritis, autoimmune gastritis, spasmolytic polypeptide‑expressing metaplasia, gastric cancer and gastric‑associated lymphomas), with the aim of providing additional targets for the treatment of gastric mucosal diseases.