Sebaceous adenoma of the eyelid: A clinical, histopathological, and immunohistochemical perspective.
Sebaceous adenoma (SA) is a rare, slow-growing benign tumor arising from sebaceous glands, accounting for less than 0.5% of all cutaneous neoplasms and approximately 1-2% of eyelid tumors. The eyelid is an uncommon site for this lesion. Histologically, SA shows well-circumscribed lobules composed of mature sebocytes with vacuolated cytoplasm and a peripheral rim of basaloid cells, without nuclear atypia or mitotic activity. We report a case of an 81-year-old man with a unilateral papillomatous lesion in the left lower eyelid, diagnosed as sebaceous adenoma on histopathology. Immunohistochemistry revealed EMA positivity and a low Ki-67 proliferative index, confirming its benign nature. The rarity of its pseudopapillomatous presentation and its need for differentiation from sebaceous carcinoma highlight the diagnostic importance of this case.
Authors
Rathod Rathod, Mishra Mishra, Swetha Swetha, Janti Janti, Zalke Zalke, Rao Rao, Khan Khan
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