Serum miR-155 as a biomarker for risk assessment and prediction of chronic complications in type 2 diabetes mellitus.
T2DM is a chronic disease with high prevalence. It can lead to a series of complications, causing severe damage to the body. The aim of the study is to examine the expression of miR-155 in patients with prediabetes and T2DM, and assessment of its diagnostic value.
The biochemical indices of 96 prediabetic patients, 96 patients with T2DM, and 60 healthy subjects were measured using related instruments. The serum expression level of miR-155 in these three groups was detected through RT-qPCR. The early diagnostic value of miR-155 for T2DM was evaluated using a Receiver Operating Characteristic (ROC) curve. The predictive value of miR-155 for chronic complications in T2DM patients was assessed using a Kaplan-Meier curve. A logistic regression analysis was used to further assess the impact of miR-155 and other factors on T2DM complications.
The expression level of miR-155 was found to be down-regulated in the serum of patients with pre-diabetes and T2DM. MiR-155 demonstrated a significant ability to differentiate between prediabetic, T2DM, and healthy individuals. T2DM patients with low miR-155 expression were found to be more susceptible to complications. Therefore, miR-155 can be considered a risk factor for T2DM complications.
The study highlighted the potential use of miR-155 in the early diagnosis and prognosis of T2DM. Additionally, miR-155 is somewhat associated with the onset and progression of T2DM complications.
The biochemical indices of 96 prediabetic patients, 96 patients with T2DM, and 60 healthy subjects were measured using related instruments. The serum expression level of miR-155 in these three groups was detected through RT-qPCR. The early diagnostic value of miR-155 for T2DM was evaluated using a Receiver Operating Characteristic (ROC) curve. The predictive value of miR-155 for chronic complications in T2DM patients was assessed using a Kaplan-Meier curve. A logistic regression analysis was used to further assess the impact of miR-155 and other factors on T2DM complications.
The expression level of miR-155 was found to be down-regulated in the serum of patients with pre-diabetes and T2DM. MiR-155 demonstrated a significant ability to differentiate between prediabetic, T2DM, and healthy individuals. T2DM patients with low miR-155 expression were found to be more susceptible to complications. Therefore, miR-155 can be considered a risk factor for T2DM complications.
The study highlighted the potential use of miR-155 in the early diagnosis and prognosis of T2DM. Additionally, miR-155 is somewhat associated with the onset and progression of T2DM complications.