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Kaposi's sarcoma (KS) is a malignant vascular neoplasm associated with human herpesvirus type 8 (HHV-8) infection. Conjunctival involvement is very rare and is considered part of classic KS. We present the case of a 57-year-old female patient with skin lesions diagnosed as classic KS not associated with HIV or immunosuppression, who later developed a conjunctival lesion. This lesion was treated with superficial radiotherapy in a single fraction using a low-energy X-ray device, resulting in good clinical outcomes and no signs of conjunctival recurrence after 5 years of follow-up. Single-fraction radiotherapy is an effective treatment for local control of the lesion and prevention of recurrence.