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Prostate cancer (PCa) is the most common malignant neoplasm of the urogenital system, with definitive diagnosis currently relying exclusively on prostate biopsy. Although the transperineal approach is associated with a lower incidence of perioperative complications, postoperative subcutaneous hematoma in the perineal region may be overlooked due to its anatomically concealed presentation, leading to delayed clinical attention. This report presents a case of extensive subcutaneous hematoma involving the lower abdomen and perineum following transperineal prostate biopsy in a patient diagnosed with PCa. Prompt management with prostatic artery angiography and superselective prostatic artery embolization, supplemented by endocrine therapy, resulted in rapid resolution of the hematoma. At three-month follow-up, tumor biomarkers remained stable, and key biochemical parameters had returned to pre-biopsy baseline levels, indicating favorable disease control and recovery.