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The SYNTAX Score II (SS II) is a clinical tool that allows individualized prediction of mortality in patients with multivessel coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). The aim was to examine whether lipid profile, uric acid and diabetes had a positive correlation with higher values of SS II. The study included 72 CAD patients. An online calculator was used to calculate SS II. Statistical tests (Mann Whitney U test and Shapiro-Wilk test) were used to assess correlations and differences in lipid profile, uric acid and diabetes status according to SS II values. There was a significant positive correlation between the proportion of patients with HDL levels above the reference values and SS II PCI. Patients with lower LDL values had significantly increased values of SS II CABG, but not SS II PCI. There was no significant correlation of total cholesterol and triglycerides with SS II PCI or SS II CABG. Patients with hyperuricemia had significantly higher SS II PCI but not SS II CABG. People with diabetes had significantly increased SS II PCI but not SS II CABG compared to non-diabetic patients. In conclusion, SS II is associated with some of the classic risk factors for atherosclerosis (uric acid, diabetes), whereas in our patient cohort there was a surprising correlation of SS II with high HDL levels and low LDL levels.