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The Community-Acquired Pneumonia, Endotypes, and Phenotypes (NACef) Dataset is a single-center dataset that includes clinical information from 768 patients diagnosed with Community-Acquired Pneumonia (CAP) at Clinica Universidad de La Sabana, Colombia. CAP continues to be a prevalent infectious condition linked to high morbidity and mortality rates during hospitalization. To help construct knowledge around this condition, this dataset encompasses Baseline Clinical Data, In-hospital follow-up, and post-hospital discharge information. This repository was captured in a prospective research study, constituting an observational cohort in translational science medicine, as we also collected biological samples to dissect the underlying mechanisms associated with severe CAP. This dataset provides opportunities for diverse statistical analyses and educational initiatives, since it contains robust clinical data and laboratory results from patients diagnosed with CAP, including data regarding COVID-19 infection. Being the first Colombian clinical database available on PhysioNet, it will contribute to a better understanding of CAP, its endotypes, and phenotypes in low- and middle-income countries (LMIC).