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The success of heart transplantation (HTX) is profoundly influenced by various psychosocial factors, underscoring the necessity of a multidisciplinary approach throughout the patient's journey. Relevant psychosocial factors, such as adherence to complex post-transplant regimens, psychological status (e.g., risk of anxiety, depression), and the long-term goal of social and professional reintegration (return to work), significantly impact post-transplant outcomes. Current guidelines strongly recommend a multidisciplinary team, including psychologists, social workers, and other specialized non-medical professionals, as their involvement is associated with better quality of care and improved long-term outcomes. This paper synthesizes the evidence underlying psychologically informed heart transplantation care, highlighting the integration of fundamental psychological principles into routine medical practice. This approach features a genuine transdisciplinary collaboration, extending beyond traditional medical care. The implementation framework includes adopting the World Health Organization's Multidimensional Adherence Model, tailored to the HTX population, and a spectrum approach to mental health, facilitating unified assessment and care aligned with the competencies of different team members. Furthermore, the collaborative team is trained in Low-Intensity Psychological Interventions, which are simple and effective; these can be embedded into routine clinical pathways by various healthcare staff to quickly address anxiety, adherence, and suboptimal health behaviors. By applying the concept of psychologically informed care, HTX centers can facilitate the genuine integration of interdisciplinary collaboration, ensuring comprehensive physical and psychosocial support for recipients.