The correlation between triglyceride-glucose index in early pregnancy (<20 weeks) and pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysis.
Insulin resistance in the early pregnancy stage can independently lead to the occurrence of gestational diabetes mellitus and adverse pregnancy outcomes. To evaluate the relationship between the Triglyceride-Glucose (TyG) index in early pregnancy and pregnancy complications and adverse pregnancy outcomes using meta-analysis.
Search the CNKI, Wanfang, VIP, China Biomedical Literature database, PubMed, Embase, Web of Science, and the Cochrane Library. The search covered the period from the establishment of each database to December 28, 2025. Two researchers using the Newcastle-Ottawa Scale to assess the quality of the included studies and extracted data. Statistical analysis was performed using RevMan 5.4 and Stata 17.0.
Twenty-three studies were included, involving 220,985 participants with 61,774 exposed individuals. Meta-analysis revealed that compared with low TyG index in early pregnancy, high TyG index was significantly associated with increased risks of gestational diabetes mellitus, gestational hypertension, preeclampsia, preterm birth, large for gestational age, and macrosomia (p < 0.05).
A high TyG index in early pregnancy is significantly positively associated with the occurrence of gestational diabetes, gestational hypertension, preeclampsia, preterm birth, large for gestational age, and macrosomia. The TyG index can serve as a simple and reliable indicator for the early diagnosis of high-risk pregnancies in pregnant women, facilitating timely clinical intervention by healthcare providers to reduce the incidence of pregnancy complications and adverse pregnancy outcomes.
https://www.crd.york.ac.uk/PROSPERO/view/CRD420261293271, Identifier CRD420261293271.
Search the CNKI, Wanfang, VIP, China Biomedical Literature database, PubMed, Embase, Web of Science, and the Cochrane Library. The search covered the period from the establishment of each database to December 28, 2025. Two researchers using the Newcastle-Ottawa Scale to assess the quality of the included studies and extracted data. Statistical analysis was performed using RevMan 5.4 and Stata 17.0.
Twenty-three studies were included, involving 220,985 participants with 61,774 exposed individuals. Meta-analysis revealed that compared with low TyG index in early pregnancy, high TyG index was significantly associated with increased risks of gestational diabetes mellitus, gestational hypertension, preeclampsia, preterm birth, large for gestational age, and macrosomia (p < 0.05).
A high TyG index in early pregnancy is significantly positively associated with the occurrence of gestational diabetes, gestational hypertension, preeclampsia, preterm birth, large for gestational age, and macrosomia. The TyG index can serve as a simple and reliable indicator for the early diagnosis of high-risk pregnancies in pregnant women, facilitating timely clinical intervention by healthcare providers to reduce the incidence of pregnancy complications and adverse pregnancy outcomes.
https://www.crd.york.ac.uk/PROSPERO/view/CRD420261293271, Identifier CRD420261293271.