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Trauma exposure and structural inequities contribute to mental health disparities among Black men and create barriers to care. Black men face elevated risk from opioid and stimulant co-use, including overdose from unintentional opioid exposure, yet heterogeneity in trauma exposure among men who co-use substances is understudied. Using latent class analysis, this study identified unobserved trauma subgroups and examined associations with cocaine use in a sample of Black men co-using opioids and stimulants; most were formerly incarcerated (88%). Three profiles emerged: Low Trauma (36%), High Non-Sexual Trauma (42%), and High Trauma Across All Categories (21%). In regression models, men in the High Trauma Across All Categories class had higher odds of lifetime powder cocaine use (OR=4.13, p<.01) and crack cocaine use (OR=2.08, p<.05) versus the Low Trauma class. Older age was associated with stimulant use, while incarceration history predicted powder cocaine use only. Findings underscore within-group heterogeneity and support trauma-informed interventions to reduce overdose risk among Black men who co-use opioids and stimulants. Targeted screening and tailored services may strengthen engagement in care and harm reduction.