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•High overall openness: Most respondents reported moderate to high willingness to use game-based interventions to improve emotion regulation, mental health, and well-being across diverse countries.•Two distinct user profiles identified: Cluster analysis revealed a high willingness group (43%) and a moderate willingness group (57%), highlighting meaningful heterogeneity in receptivity.•Key predictors of high willingness: Younger age (18-25), male gender, frequent gaming, gaming disorder symptoms, and specific emotion regulation difficulties significantly increased likelihood of high willingness.•Factors associated with lower willingness: Higher impulsivity (low perseverance, high sensation seeking) and emotional unawareness or limited use of regulation strategies were linked to reduced openness.•One of the key findings: Participants showed lower willingness to use game-based interventions preventively than reactively.