ZOMES: expanding roles of the PCI complexes from protein metabolism to drug discovery.
The XII-ZOMES Conference (Shenzhen, 2024) showcased advances in PCI complexes—proteasome, COP9 signalosome, and eIF3—which regulate cellular proteostasis through conserved architectures. Presentations covered translation initiation, proteasome assembly, ubiquitin and ubiquitin-like modification regulation, protein quality control mechanisms, and emerging therapeutic technologies including PROTACs and molecular glues for targeted protein degradation.