Background: Hyperlipidemia represents a pivotal risk factor for multiple cardiovascular and metabolic diseases, creating an urgent demand for safe, effective novel therapeutic interventions. Resveratrol (RES), a natural plant polyphenol, has exhibited great potential as a hypolipidemic agent for hyperlipidemia treatment. Methods: In this work, we established a high-fat diet (HFD)-induced hyperlipidemic mouse model to systematically investigate the lipid-regulating efficacy of RES. Results: Oral administration of RES significantly decreased serum levels of total cholesterol and low-density lipoprotein cholesterol, while markedly increasing high-density lipoprotein cholesterol concentrations. Histopathological analyses further demonstrated that RES alleviated HFD-induced hepatic and ileal injury. Moreover, RES significantly decreased the circulating levels of several bile acids (BAs), including taurodeoxycholic acid, taurolithocholic acid, lithocholic acid, and tauro-(α + β)-muricholic acid. RES also ameliorated HFD-induced gut microbial dysbiosis, as evidenced by a reduction in the Firmicutes/Bacteroidetes ratio, increased relative abundances of non_f_Muribaculaceae, Lactobacillus, Ileibacterium, and Bacteroides, and decreased abundances of Lachnospiraceae_NK4A136_group and unclassified f_Lachnospiraceae. Spearman correlation analysis revealed significant associations between gut microbial taxa and BA profiles, suggesting that coordinated regulation of the gut microbiota and BA metabolism contributes to the hypolipidemic effects of RES. Conclusions: Collectively, RES alleviates HFD-induced hyperlipidemia by remodeling gut microbiota composition and restoring bile acid metabolic homeostasis.

Suicide remains a major public health challenge worldwide, particularly among socially vulnerable populations who experience disproportionate exposure to social determinants associated with suicide risk and barriers to mental healthcare. Primary health care (PHC) is often the first point of contact with healthcare services and therefore plays a critical role in suicide prevention.

This narrative review was conducted according to the SANRA guidelines. A structured literature search of PubMed/MEDLINE, Scopus, and Web of Science was performed to identify evidence on suicide prevention interventions implemented in PHC and their applicability to socially vulnerable populations. The review focused on intervention characteristics, implementation approaches, reported outcomes, and challenges relevant to PHC practice.

The reviewed literature indicates that suicide prevention in PHC relies on multiple complementary strategies, including suicide risk screening, collaborative care models, safety planning interventions, brief psychological interventions, telehealth approaches, continuity-of-care programs, and provider training. Evidence suggests that multicomponent and integrated approaches are generally more effective than isolated interventions. Socially vulnerable populations, including people experiencing homelessness, poverty, unemployment, migration, domestic violence, substance use disorders, social isolation, disability, and social marginalization, face additional barriers to accessing mental healthcare and suicide prevention services. Effective interventions frequently combine clinical care with community, social, and support services to address both mental health needs and underlying social determinants of suicide risk.

Suicide prevention in PHC requires integrated, multidisciplinary, and person-centered approaches that extend beyond risk identification alone. Strengthening service integration, continuity of care, provider capacity, and intersectoral collaboration may improve suicide prevention efforts, particularly among socially vulnerable populations. Further research is needed to evaluate implementation strategies and intervention effectiveness in diverse healthcare settings, especially in low- and middle-income countries.

Burnout is prevalent among nurses, particularly in Intensive Care Units (ICUs), where work is characterized by high intensity, high risk, and heavy workloads. This condition not only directly impairs nurses' physical and mental health and reduces their occupational retention rate but may also threaten the safety of ICU patients due to potential declines in the quality of nursing care. Given these implications, effective alleviation of burnout among ICU nurses is essential for promoting their well-being, stabilizing the nursing workforce, and improving patient satisfaction. Previous studies have explored various variables related to burnout among ICU nurses, such as psychological capital, social support, work-family conflict, and moral distress. However, these findings remain inconsistent and fragmented across studies. To date, a comprehensive quantitative synthesis of the correlations between these variables and burnout among ICU nurses is lacking. Therefore, this study conducted a meta-analysis based on Pearson correlation coefficients to examine the correlates of burnout among ICU nurses, aiming to provide more reliable evidence for the development of targeted intervention strategies for this population.

Databases including CNKI, Wanfang Database, VIP Database, China Biomedical Literature Database (CBM), PubMed, Web of Science, Embase, CINAHL, and Cochrane Library were systematically searched. The search used terms for intensive care units, nurses, burnout, and China in both Chinese and English. The search was conducted from the inception of the database to September 2025. Two researchers with expertise in evidence-based practice performed the literature search, independently screened studies based on the inclusion and exclusion criteria, assessed the quality of the included studies using the Agency for Healthcare Research and Quality (AHRQ)'s quality assessment criteria for observational studies, and extracted relevant data. A meta-analysis was conducted using RevMan 5.4 software, with Pearson correlation coefficients (r values) as the outcome indicator.

A total of 31 studies were included, with a combined sample size of 8,219 participants, and the overall methodological quality of the included studies was moderate. The pooled analysis indicated that burnout was significantly negatively correlated with psychological capital (r = -0.43, 95% CI: -0.53 to -0.33, I ² = 81%), research competence (r = -0.21, 95% CI: -0.30 to -0.11, I ² = 0%), and social support (r = -0.40, 95% CI: -0.49 to -0.28, I ² = 82%) (p < 0.01). Burnout was positively correlated with work-family conflict (r = 0.49, 95% CI: 0.41-0.57, I ² = 69%), presenteeism (r = 0.33, 95% CI: 0.24-0.41, I ² = 0%), moral distress (r = 0.32, 95% CI: 0.16-0.46, I ² = 53%), turnover intention (r = 0.48, 95% CI: 0.24-0.66, I ² = 96%), and alarm fatigue (r = 0.55, 95% CI: 0.26-0.75, I ² = 95%) (p < 0.01). Substantial heterogeneity was observed in several pooled estimates, particularly for turnover intention and alarm fatigue.

This meta-analysis suggests that burnout among ICU nurses is associated with multiple occupational and psychosocial factors, including work-family conflict, turnover intention, presenteeism, social support, and psychological capital. These findings highlight the importance of work-related stressors and psychological resources in relation to burnout among nurses. However, given the heterogeneity across studies and the cross-sectional nature of the included evidence, these associations should be interpreted with caution. The results provide a synthesized overview of the factors related to burnout among ICU nurses and may help inform future research and the development of strategies aimed at supporting nurses' occupational well-being.

This study was registered in the PROSPERO database (registration number: CRD420251146719). The protocol predefined the research objectives, inclusion and exclusion criteria, and main analytical methods. This study was conducted in accordance with the registered protocol. If minor adjustments were made during the study due to data availability, they were clearly described and justified in the Methods section to improve transparency and reproducibility.

In January 2025, the Trump Administration announced a 90-day freeze on all US government (USG) foreign aid, which subsequently became a permanent shutdown of the US Agency for International Development in July 2025. The sudden withdrawal of USG financing disrupted health and humanitarian systems worldwide, with disproportionate impacts on women, girls and other marginalised populations. This study documents impacts of the funding freeze during its early months (February-March 2025) on global health programmes.

This rapid mixed-methods assessment combined a global online survey with qualitative case studies in Nepal, Kenya and Colombia. The survey was distributed via email through networks and relevant listservs. Semistructured key informant interviews (KIIs) (n=53) were conducted with non-governmental organisation leaders, clinicians, community health workers, government officials and humanitarian actors, all purposively selected based on their direct or indirect involvement in USG-funded health programmes. Interview transcripts were thematically analysed and triangulated with quantitative findings.

Survey respondents reported initial impacts of the USG funding cuts across health sectors and functions, including humanitarian and emergency response/preparedness, gender-based violence and mental health and psychosocial support. Five key themes arose from the KIIs with stakeholders in three case study countries: disruptions to sexual and reproductive health and rights (SRHR) services, HIV service interruptions and treatment access, the collapse of referral networks and service ecosystems, a mental health crisis among clients and health workers and the rising vulnerability of marginalised populations. Both survey and interview data highlighted growing inequities and anticipated reversals in longstanding health gains.

The 2025 US foreign aid freeze generated immediate and widespread disruptions across health and humanitarian systems, revealing systems-level vulnerabilities. These early findings point to the need for more diversified and reliable financing, stronger domestic preparedness and policy approaches that centre SRHR and marginalised populations.

Newly arrived immigrants to the USA who have time-sensitive medical or mental health needs face a fragmented and often insufficient system of support. This qualitative study explored the perspectives of individuals and organisations who support immigrants across their immigration journey and sought ideas to better identify and connect people in need with care.

From June to August 2024, semistructured consultative sessions were conducted with individuals working with recently arrived immigrant families across both sides of the US Southern border, as they transition to and arrive at their US destination. Reflexive thematic analysis was used by researchers with relevant lived experience to interpret the data and develop the analytic themes.

A total of 58 individuals representing 35 organisations from 14 US states and Mexico participated in the study. Participants came from a wide range of sectors including academic institutions, border respite centres, community-based organisations on both sides of the US-Mexico border, local government and Customs and Border Protection officials, health navigators, nurse midwives and physicians. Qualitative analysis of interviews revealed key themes including gaps in identification and access to care for medically at-risk immigrants at the border and throughout the USA, extensive violence and trauma that many experience and subsequent need for acute and long-term mental health support, unique social, linguistic and structural barriers faced by this population and finally the need for innovative solutions and health-centric policies to address these complex issues.

Although the immigration landscape is constantly changing, certain fundamental medical and health-related social needs remain constant. Innovative solutions are required to improve the health and well-being of immigrants. This can only be achieved by elevating the expertise of the people and organisations who engage directly with immigrants on their journey.

Stigma and a lack of knowledge are significant barriers to seeking mental health support, particularly among adolescents. In Iran, there is a scarcity of interventional studies addressing these issues, and the findings from existing research are often inconsistent. This study translated and culturally adapted the Canadian Guidance about Mental Health and the High School Curriculum for implementation in Iranian schools to address this gap. This study aims to determine the effect of this educational intervention on the mental health literacy of Iranian students.

This research employed a quasi-experimental design involving a sample of two hundred middle school children aged 14.28 ± 0.7 years, ranging from 13 to 16 years old. The educational intervention for the experimental group consisted of six sessions, each lasting 45 to 60 minutes. Data were collected using the Knowledge and Attitudes to Mental Health Scales (KAMHS). The data were analyzed using inter-group and intra-group repeated measures ANOVA, with a significance cutoff of P<0.05.

There were no significant differences in demographic characteristics between the intervention and control groups. However, the intervention group demonstrated significant improvements in mental health behaviors, a reduction in stigma, and an increase in help-seeking, while the control group showed no such changes (P<0.05).

The designed intervention was effective in increasing knowledge and attitudes.

Understanding how Americans think about public health and the role of government institutions is crucial for informing effective health communication in a polarized political climate.

We deployed an open-ended national survey of 1004 adults in October 2025 to assess public perceptions of these topics.

Respondents associated the term "public health" with health for everyone (44%) and health of everyone (23%), alongside healthcare (20%) and other themes. The most common perceived government benefit was facilitating access to healthcare (39%)-particularly by addressing cost (16%). Among perceived government harms, more Republicans than Democrats cited overregulation (16% vs 8%, P < 0.01), limiting personal freedoms (16% vs 6%, P < 0.001), and inefficiency (10% vs 4%, P < 0.01); more Democrats than Republicans mentioned dismissing science (7% vs 2%, P < 0.01) and defunding (7% vs 2%, P = 0.02). Weighted analyses yielded minimal substantive differences from unweighted findings.

Findings reveal both cross-partisan common ground in term associations and divergent concerns regarding government action. Public health messaging should leverage shared priorities and acknowledge partisan concerns about government roles.

Nature exposure has been associated with improvements in physiological, emotional, and cognitive functioning. However, workplace research has primarily focused on visual access to nature, despite nature being inherently a multisensory experience. Drawing on Attention Restoration Theory (ART), Stress Reduction Theory (SRT), and emerging work on olfactory environments ("smellscapes"), this study examines how visual and olfactory nature stimuli independently and jointly influence cognitive and behavioral outcomes in workplace settings.

A between-subjects experiment (N = 256) employed a 2 × 2 design (visual: present vs. absent × olfactory: present vs. absent). Participants completed tasks assessing attention, memory recall, abstract reasoning, risk aversion, and dishonest behavior. Outcomes were analyzed using two-way factorial ANOVA to evaluate the independent and combined effects of exposures, with supplementary one-way ANOVA conducted across the four conditions. Blink rate was also recorded via continuous eye-tracking as a physiological indicator of cognitive load, alongside facial expression data to contextualize affective responses.

Effects varied by sensory condition and outcome. Visual exposure was associated with improvements in attention and abstract reasoning, whereas olfactory exposure was associated with memory performance and dishonest responding. Significant interactions were observed for several outcomes, including attention, memory, risk-taking, and dishonest responding. Blink rates were generally lower under nature exposure conditions than in the control condition. Physiological measures indicated reduced blink rates under nature exposure conditions relative to control environments, suggesting differences in visual attention and task engagement across experimental conditions.

These findings suggest that multisensory nature exposure differentially influences cognitive and behavioral processes in workplace environments rather than producing uniform benefits. By demonstrating that low-cost, passive interventions such as visual and olfactory cues can shape attention, decision-making, and mental overload, this study advances environmental psychology and supports the integration of multisensory design strategies to enhance workplace functioning and overall productivity.

PurposeThis study examined whether the frequency and duration of participation in community cafes-nonprofit, pay-what-you-can restaurants-are associated with food security, dietary improvement, and psychosocial well-being among adult patrons.DesignCross-sectional, multi-site observational study using an instrumental-variables regression framework to reduce selection bias.SettingEleven community cafes operating under the pay-what-you-can model across the U.S.SampleThe analytic sample included 137 adult patrons who had eaten at a cafe within the past month (65% female, 65.7% White).MeasuresPrimary exposures were the frequency of cafe meals and the duration since first visit. Outcomes included food security (USDA six-item module), self-reported dietary improvement, social connectedness, and loneliness. Covariates included gender, race, and cafe site fixed effects.AnalysisTwo-stage instrumental-variable regression models used geographic distance as an instrument for cafe participation. Logistic regression estimated odds of food security, and linear models examined continuous outcomes (P < 0.05). Estimates are interpreted as local effects for patrons whose participation is influenced by access.ResultsLonger duration since first cafe visit was associated with higher odds of being food secure (OR = 2.93, 95% CI = 1.21-7.09). No significant associations were observed for dietary or psychosocial outcomes.ConclusionSustained engagement in cafes is associated with a greater likelihood of being food secure, indicating the importance of long-term participation in dignity-based health promotion strategies.

PurposeThis study examined: (1) availability of mental health-promoting interventions (MHPIs) in Quebec elementary schools in relation to area-level socioeconomic advantage, prioritization of student mental health, parent and community engagement, school climate; and (2) the extent to which existing MHPIs incorporated evidence-informed implementation practices.DesignCross-sectional.SettingPublic elementary schools across Quebec, Canada (n = 171).SubjectsSchool principals and vice-principals (n = 171 for Objective 1; n = 43 for Objective 2).MeasuresStructured telephone interviews using standardized French or English closed-ended questionnaires.AnalysisDescriptive statistics and unadjusted association analyses.ResultsOnly 42% of schools offered an MHPI in the past year, with socioeconomically disadvantaged schools less likely and schools prioritizing mental health, engaging parents and community partners, and fostering supportive school environments more likely to do so. Most MHPIs incorporated multiple competencies and active learning approaches, were institutionalized, and were adapted to local contexts. Few MHPIs involved co-design with teachers, parents, or students, and only half incorporated staff training or formal evaluation.ConclusionMHPI availability in Quebec elementary schools was socially patterned. While many existing MHPIs demonstrated substantial alignment with evidence-informed implementation practices, important gaps remained in stakeholder engagement, capacity building, and evaluation. Strengthening funding, staff training, and implementation support may improve the reach, quality, and equitable delivery of school-based mental health promotion.