In line with sport psychology's growing focus on wellbeing and mental health, meaning (i.e., experiencing life as coherent, significant, oriented, and belonging) has been gaining attention in elite sport. Its study is theoretically and practically relevant, since athletes often refer to meaning, especially when it is lacking. However, while wider research highlights its role for physical and mental health, empirical inquiry in sport psychology has produced diverse conceptualizations and lacking alignment with psychological theory. This makes it difficult for practitioners to address meaning when its nature, threats, and supports remain unclear. To address this gap, our study sought to (a) provide an empirical account of athletes' lived experience of meaning, (b) advance theoretical integration with psychological frameworks by proposing a contextualized model of meaning in elite sport that draws on pertinent meaning in life theory, and (c) facilitate applied work. To this end, we interviewed 13 international Olympic athletes multiple times from February 2022 to August 2024. Through framework analysis, we developed an empirical model, incorporating the dimensions of coherence, significance, purpose, belonging, alongside the psychological needs for autonomy, competence, relatedness, and contribution. The model identifies two routes to experiencing meaning in elite sport: Self-actualization arises when athletes connect to themselves through feeling self-determined, competent, mattering to themselves, and having a personal purpose. Self-transcendence emerges when athletes connect with others by pursuing a wider purpose, mattering to others, contributing through giving back, and nurturing relationships. We conclude with critical reflections and recommendations for supporting both routes in practice.

Crisis response planning (CRP) reduces suicide attempts and suicidal ideation among high-risk patients, yet little is known about how it alters the processes through which suicidal ideation emerges and resolves. This study examined dynamic interactions among positive affect (PA), negative affect (NA), and suicidal ideation (SI) in treatment-seeking U.S. military personnel and veterans with posttraumatic stress disorder (PTSD) who received CRP or safety planning prior to PTSD treatment.

This secondary analysis used ecological momentary assessment (EMA) data from a randomized clinical trial comparing CRP and safety planning (SP) delivered alongside massed cognitive processing therapy for PTSD (N = 116). Participants completed four EMA surveys per day for 14 days assessing PA, NA, and SI. Differential equation modeling was used to estimate temporal stability and cross-variable coupling, followed by eigenvalue and eigenvector decomposition to characterize system organization and patterns of change.

Across interventions, PA, NA, and SI exhibited negative autocorrelation effects indicating temporal stability; however, SI showed weak self-regulation, suggesting greater persistence once elevated. Coupling patterns differed by intervention. In SP, NA was directly coupled with SI, indicating distress readily translated into suicidal thinking. In contrast, CRP showed coupling between NA and PA rather than SI, suggesting distress was regulated before activating suicidal ideation. Follow-up analyses further indicated that CRP strengthened affective regulation and integrated SI with affective processes.

Although both interventions produced stable cognitive-affective systems, CRP uniquely altered the relationships among affect and suicidal ideation, promoting regulatory feedback loops that may reduce vulnerability to acute suicidal risk.

Continuous positive airway pressure (CPAP) treatment brings more benefits to most patients with obstructive sleep apnea (OSA), especially OSA patients with coronary heart disease(CAD). These patients often have emotional disorders such as anxiety and depression, which have a negative impact on their clinical prognosis.

To investigate whether CPAP can improve anxiety, depression, and inflammatory cytokine levels in patients with OSA with and without comorbid CAD.

72 patients were randomly assigned to a CPAP group or a control group. The CPAP group received conventional OSA management plus CPAP therapy, while the control group received only routine OSA treatment. All CAD patients in both groups received standardized CAD treatment. Peripheral blood test reports were collected from each patient at the beginning of treatment and at 6 and 12 months, and the Hospital Anxiety and Depression Scale (HADS) was used for evaluation.

After 12 months of treatment, the HADS anxiety and depression scores of patients in the CPAP group were significantly improved compared to those in the control group, and the levels of inflammatory factors such as white blood cells (WBC), neutrophils (N), C-reactive protein (CRP), interleukin-6 (IL-6), and procalcitonin (PCT) were also decreased markedly.

12 months of CPAP treatment significantly alleviates anxiety and depression in OSA patients, especially those with CAD, and lowers systemic inflammation . More attention should be paid to the relationship between OSA and emotional disorders, particularly in CAD patients. This not only benefits patients' physical well-being, but also supports their mental health.

Somatic Symptom Disorder (SSD) and Functional Neurological Disorder (FND) are among the most prevalent conditions within the DSM-5 category of somatic symptom and related disorders (SSRD) and are associated with substantial psychological distress and functional impairment. Although the aetiology of SSRD is multifactorial and remains uncertain, emerging evidence suggests that impairments in mentalizing - the capacity to understand one's own and others' mental states - may contribute to the development and persistence of functional somatic symptoms. Despite growing research interest, no systematic review has synthesised the evidence comparing mentalizing abilities in individuals with SSD or FND to those without these diagnoses. The present systematic review addressed this gap by examining whether individuals with SSD and FND differ in mentalizing relative to healthy and clinical control groups, focusing on studies explicitly assessing mentalizing-related constructs. A comprehensive search of three electronic databases identified 18 eligible studies, comprising 1801 participants. Methodological quality was appraised using the Joanna Briggs Institute (JBI) Critical Appraisal Tool for case-control studies, and the psychometric robustness of mentalizing measures was critically evaluated. Overall, adults with SSD and FND - particularly those with psychogenic non-epileptic seizures (PNES) - demonstrated impairments in other-focused cognitive mentalizing compared to control groups. In contrast, self-focused mentalizing was rarely assessed, precluding firm conclusions. Findings suggest that mentalizing may be clinically relevant in SSD and FND and support further investigation of mentalization-informed assessment and intervention. However, substantial diagnostic and measurement heterogeneity underscores the need for high-quality, adequately powered studies employing validated, multidimensional assessments of mentalizing.

Subjective Cognitive Decline (SCD) is considered a risk stage for future cognitive impairment and dementia.

This study examined whether different neuropsychological criteria for defining cognitive normality influence SCD's ability to predict conversion to dementia.

Participants from the Cognitive Complaints Cohort were diagnosed according to the Subjective Cognitive Decline Initiative criteria. Normal cognition was defined by the absence of Mild Cognitive Impairment according to five Jak and Bondi criteria. Sociodemographic, clinical, and neuropsychological data were analyzed using descriptive statistics. Bootstrap methods characterized group profiles given overlap between SCD definitions. Kaplan-Meier curves illustrated time to dementia, and a clustered Cox proportional hazards model accounted for overlapping group membership and adjusted for baseline variables.

Among 838 subjects, the five SCD groups showed similar age and sex distributions but differed in education, cognition, and functional status, while subjective complaints and depressive symptoms did not differ meaningfully. Kaplan-Meier curves showed variability in conversion probabilities. At five years, conversion ranged from 3.9% (Liberal) to 25.5% (Conservative); at ten years, from 16.2% to 40.9%. Clustered Cox analysis showed that Conservative and Historical SCD remained associated with higher hazard of conversion after adjustment, whereas Typical and Comprehensive SCD were associated with lower hazard estimates.

Neuropsychological criteria for cognitive normality define SCD groups with distinct clinical profiles and risks of dementia. Broader definitions identify individuals at higher risk, whereas more stringent definitions capture populations with lower likelihood of decline, highlighting the importance of criterion selection according to clinical and research objectives.

Borderline Personality Disorder (BPD) is characterized by emotional dysregulation and high-risk behaviors, including self-harm and suicide attempts. Despite the high prevalence of suicidal behavior in BPD, the neurobiological substrates underlying suicide vulnerability remain poorly understood. This study aimed to investigate differences in BPD and a history of suicide attempt (BPD-SA) with those without such a history (BPD-NA) using multimodal magnetic resonance imaging (MRI).

Neuroimaging data from 60 individuals with BPD were analyzed. Acquisitions included high-resolution T1-weighted, Fluid-Attenuated Inversion Recovery sequences, and Diffusion Weighted Imaging. Imaging features were compared between BPD-SA (n = 30) and BPD-NA (n = 30) subgroups, adjusting for alcohol and substance abuse. Pearson's correlation was used to examine associations between imaging features and clinical questionnaires, including childhood trauma and symptom severity.

Significant differences (p < 0.05) were found between BPD-SA and BPD-NA in brain volume, cortical thickness, and Fractional Anisotropy. The most pronounced changes were localized to limbic structures (hippocampus and fornix), the frontal cortex, corpus callosum, and cortico-thalamic pathways, with BPD-SA showing more severe white matter alterations. Correlation analyses revealed that imaging abnormalities in BPD-SA were negatively correlated with the Childhood Trauma Questionnaire (CTQ). In contrast, Zanarini Rating Scale (ZAN-BPD) scores were negatively correlated with MRI-assessed neurobiological alterations only in the BPD-NA subgroup.

This study provides preliminary evidence that BPD-SA may exhibit distinct patterns of structural and white matter alterations compared to BPD-NA. Such neuroimaging differences may reflect underlying neurobiological dimensions related to vulnerability, illness severity, and developmental risk exposure.

This study aimed to analyze 490 existing studies on visual-motor integration in early childhood using bibliometric methods and to reveal the accumulated knowledge, research orientation, and thematic areas in this field of research. The data were obtained from the Web of Science Core Collection database and analyzed using Bibliometrix (Rpackage) and VOSviewer software. Our findings indicate that research on visual-motor integration in early childhood spans approximately 40 years and has shown an uneven but overall increasing trend since 2010, with an annual growth rate of 6.49%. Our analyses indicate that the most productive countries in terms of publications are the United States and China. Thematic analysis revealed that intelligence, psychomotor performance, grip strength, academic achievement, autism, and handwriting fluency are the main research areas of the study. When examining the most recent topics studied, themes such as developmental coordination disorder, obesity, self-regulation, physical activity, early childhood education, mental disability, and hand-eye coordination emerged. Our study emphasizes the interdisciplinary nature of visual-motor integration skills in early childhood and highlights the importance of focusing on these skills because they play a critical role in developmental stages.

As a core component of negative affectivity, high trait anxiety (HTA) elevates the risk of the onset of depressive disorders through impaired emotion regulation processes. However, its underlying neural mechanisms remain unclear due to methodological constraints. This study addressed these gaps by integrating event-related potential (ERP), nonlinear analysis, and machine learning (ML), while controlling for emotion regulation strategy use habits. We recruited 33 college students with HTA and 30 with low trait anxiety (LTA), who performed cognitive reappraisal and expressive suppression during emotion regulation. ERP results showed that both groups reduced P2 amplitudes for negative stimuli via the two regulation strategies. However, HTA individuals only downregulated centro-parietal LPP in the early stage (500-1000 ms) and failed to maintain this effect in the late stage, indicating impaired sustained emotion regulation. Nonlinear and correlation analyses revealed that lower wavelet entropy (reflecting less flexible brain states) was associated with poorer sustained reappraisal in HTA individuals, implying that reduced neural complexity may underlie deficits in prolonged regulation. Group differences vanished after controlling for depressive symptoms, implying such neural abnormalities stem from a general negative affectivity predisposition rather than trait anxiety alone. ML further identified reappraisal-related LPP and wavelet entropy modulation as the most discriminative features for this negative affectivity phenotype. These results provide a theoretical foundation for translational research and may aid in the early identification of individuals at high risk for such disorders.

To investigate the landscape of targetable genomic alterations and programmed cell death ligand 1 (PD-L1) expression in pulmonary ground-glass opacities (GGOs) and their association with age.

A total of 2509 patients with GGOs were retrospectively analyzed. Tumor characteristics, PD-L1 expression, and prevalence of targetable alterations were compared across age groups.

In GGOs, the mutation rates of EGFR (61.5%) and ERBB2 (12.0%) were relatively high, whereas those of KRAS (8.2%) and ALK rearrangements (2.3%) were relatively low. The patients exhibited a low tumor mutational burden (TMB), and PD-L1 expression was negative in 86.7% of cases. TMB, PD-L1 expression, and the mutation rates of EGFR, KRAS, and MET increased significantly with age, whereas the rates of ERBB2 mutations, ALK rearrangements, and RET rearrangements decreased significantly with age. Age was identified as an independent predictor for the above eight variables. The optimal age cutoff was determined to be 53 years. Compared with the younger age group (< 53 years), the older age group (≥ 53 years) showed a 31.6%, 130.4%, and 800.0% higher likelihood of harboring EGFR, KRAS, and MET mutations, respectively. Conversely, compared with the older age group, the younger age group showed a 289.1%, 94.1%, and 108.7% higher likelihood of harboring ERBB2 mutations, ALK rearrangements, and RET rearrangements, respectively.

GGOs exhibit a distinct genomic and PD-L1 profile with significant age-related heterogeneity, providing insights for age-stratified therapeutic strategies.

Ovarian Cancer (OC), the deadliest gynecological malignancy, poses a major therapeutic challenge in advanced stages owing to its high recurrence rate and metastatic potential. In this regard, it is noteworthy that immunotherapy has recently gained significant attention in OC treatment, a phenomenon attributable to notable advances in over-the-counter Chimeric Antigen Receptor (CAR)-based cell therapy. At the heart of CAR-T Cell (CAR-T) immunotherapy is genetically modified CAR molecules that enable immune cells to target and recognize tumor antigens. Based on such strategies, CAR-T therapies have developed rapidly in hematological oncology and are gradually being extended to solid tumors. Despite their potential in OC treatment, several factors, including off-target effects attributable to the lack of Tumor-Specific Antigens (TSAs), as well as severe side effects such as tumor immune barriers, Cytokine Release Syndrome (CRS), and neurotoxicity, have been established to limit the clinical use of CAR-T therapies. Moreover, compared to CAR-T, CAR-Natural Killer (NK) and CAR-Macrophage (M) therapies have distinct advantages. The killing mechanism of NK cells integrates both CAR-dependent and non-dependent pathways, avoiding severe CRS and neurotoxicity. Furthermore, besides directly phagocytosing tumors due to its strong ability to infiltrate tumors, CAR-M therapy could also effectively improve the Immunosuppressive Microenvironment (IME) via immunomodulatory factor secretion to remodel M2-type Tumor-Associated Macrophages (TAMs) into the M1 phenotype with anti-tumor function. In this review, we systematically describe the research progress in CAR-T therapy for OC and compare the similarities and differences of three types of cellular therapies (CAR-T, CAR-NK, and CAR-M) regarding their mechanisms of action, clinical advantages, and technological bottlenecks. We hope that our findings will provide a theoretical basis for optimizing immunotherapeutic strategies for OC. Trial Registration: ClinicalTrials.gov identifier: NCT03585764.